Protein Alignment Hr83 and Nr2e1

DIOPT Version :10

• Sequence 1: NP_649647.1
• Gene: Hr83 / 40783
• FlyBaseID: FBgn0037436
• Length: 278
• Species: Drosophila melanogaster
• Sequence 2: NP_689415.1
• Gene: Nr2e1 / 21907
• MGIID: 1100526
• Length: 385
• Species: Mus musculus
• Alignment Length: 340
• Identity: 107/340 - (31%)
• Similarity: 149/340 - (43%)
• Gaps: 97/340 - (28%)

  Fly     7 CAVCGDQSSGKHYGVSCCDGCSCFFKRSVRRGSSYAC-IALVGNCVVDKARRNWCPSCRFQRCLA 70
            |.||||:||||||||..|||||.|||||:||..:|.| ....|.|.|||..||.|.:||.::||.
Mouse    16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLE 80

  Fly    71 VGMNAAAVQEERGPR----NQQVALYRTGRRQAP------PSQAAPSP----------------- 108
            |.||..|||.|||||    .:|||||..|.::..      ||.|.|:|
Mouse    81 VNMNKDAVQHERGPRTSTIRKQVALYFRGHKEDNGAAAHFPSTALPAPAFFTAVTQLEPHGLELA 145

  Fly   109 ----TPHSQAL-----------H---------FQI--------LAQILVTCLRQAKANEQFALLD 141
                ||..|.|           |         :::        .|::|...::.||:...|:.|.
Mouse   146 AVSATPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLS 210

  Fly   142 RCQQDAIFQVVWSEIFVLRASHWSLDISA---------MIDGCGDEQLKRLICEA---------- 187
            ...|..:.:..|.|:|||..:.|::.:.|         ..|....::|.::|.|.
Mouse   211 LQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNTDNTDSQKLNKIISEIQALQEVVARF 275

  Fly   188 HQLRADVLELNFMESLILCRKELAINAEYAVILGSHSKAALISL----ARYTLQQSNYL------ 242
            .|||.|..|...::.::..:   |:.......|.|...||.|:.    |:.||  ::|:
Mouse   276 RQLRLDATEFACLKCIVTFK---AVPTHSGSELRSFRNAAAIAALQDEAQLTL--NSYIHTRYPT 335

  Fly   243 ---RFGQLLLGLRQL 254
               |||:|||.|..|
Mouse   336 QPCRFGKLLLLLPAL 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr83	NP_649647.1	NR_DBD_PNR_like_2	7..88	CDD:143515	50/85 (59%)
Nr2e1	NP_689415.1	NR_DBD_TLX	8..99	CDD:143537	50/82 (61%)
		NR_LBD_Tlx_PNR_like	154..369	CDD:132748	44/202 (22%)
		Required for transcriptional repression	341..385		6/10 (60%)