DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr83 and Rxra

DIOPT Version :9

Sequence 1:	NP_649647.1	Gene:	Hr83 / 40783	FlyBaseID:	FBgn0037436	Length:	278	Species:	Drosophila melanogaster
Sequence 2:	NP_035435.1	Gene:	Rxra / 20181	MGIID:	98214	Length:	467	Species:	Mus musculus

Alignment Length:	325	Identity:	94/325 - (28%)
Similarity:	143/325 - (44%)	Gaps:	59/325 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSNFS--ACAVCGDQSSGKHYGVSCCDGCSCFFKRSVRRGSSYACIALVGNCVVDKARRNWCPSC 63
            |::|:  .||:|||:||||||||..|:||..||||:||:..:|.| ....:|::||.:||.|..|
Mouse   132 MASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTC-RDNKDCLIDKRQRNRCQYC 195

  Fly    64 RFQRCLAVGMNAAAVQEER---GPRNQQVALYRTGRRQAPP------SQAAPSP----------- 108
            |:|:|||:||...||||||   ..||:......:...:..|      ::.|..|
Mouse   196 RYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKILEAELAVEPKTETYVEANMG 260

  Fly   109 ----TPHSQALHF-QILAQILVTCLRQAKANEQFALLDRCQQDAIFQVVWSEIFVLRASHWSLDI 168
                :|:....:. |...:.|.|.:..||....|:.|....|..:.:..|:|:.:...||.|:.:
Mouse   261 LNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAV 325

  Fly   169 ---------------SAMIDGCG---DEQLKRLICEAHQLRADVLELNFMESLILCR---KELAI 212
                           ||...|.|   |..|..|:.:...::.|..||..:.:::|..   |.|:.
Mouse   326 KDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSN 390

  Fly   213 NAEYAVILGSHSKAALISLARYTL----QQSNYLRFGQLLLGLRQLCLRRFDCALSCMFRSVVRD 273
            .||...:    .:....||..|..    :|..  ||.:|||.|..|......|.....|..::.|
Mouse   391 PAEVEAL----REKVYASLEAYCKHKYPEQPG--RFAKLLLRLPALRSIGLKCLEHLFFFKLIGD 449

Fly 274 273
Mouse 450 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr83	NP_649647.1	NR_DBD_PNR_like_2	7..88	CDD:143515	46/83 (55%)
Rxra	NP_035435.1	Modulating domain. /evidence=ECO:0000250	1..139		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..112
		Nuc_recep-AF1	18..131	CDD:288658
		NR_DBD_RXR	138..214	CDD:143514	42/76 (55%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P19793	165..170		3/4 (75%)
		Hinge	206..229		8/22 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..233		6/21 (29%)
		NR_LBD_RXR_like	234..445	CDD:132741	45/216 (21%)
		Required for nuclear export. /evidence=ECO:0000250\|UniProtKB:P19793	353..373		4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840