DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Znrf3 and znrf3

DIOPT Version :9

Sequence 1:	NP_001074393.1	Gene:	Znrf3 / 407821	MGIID:	3039616	Length:	913	Species:	Mus musculus
Sequence 2:	NP_001072864.1	Gene:	znrf3 / 780325	XenbaseID:	XB-GENE-5937936	Length:	853	Species:	Xenopus tropicalis

Alignment Length:	930	Identity:	537/930 - (57%)
Similarity:	612/930 - (65%)	Gaps:	127/930 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    18 RLRRGPRGRRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTHTTGLTGRF 82
            |:|.|           |||:...:|.|..||.:.||||||||||||||||:|||.||||.|.|||
Frog     5 RIRGG-----------LPLVWLWVLLAVAPGESLAKETAFVEVVLFESSPNGDYKTHTTELQGRF 58

Mouse    83 SRAGAMLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRG 147
            |||||.:||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||
Frog    59 SRAGATISAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPEMDPKPCLTVLGKAKRAVQRG 123

Mouse   148 ATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHLPPRQPTE 212
            |||||||||:||:|::|||||.||||||||||:||.|||||||||||||.|||||||.|||||||
Frog   124 ATAVIFDVSDNPDAVEQLNQGLEDPLKRPVVYMKGMDAIKLMNIVNKQKGARARIQHRPPRQPTE 188

Mouse   213 YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCG 277
            ||||||||||||||||||||||:|||||||||||||||:|||||||||||||.:|.|..||||||
Frog   189 YFDMGIFLAFFVVVSLVCLILLIKIKLKQRRSQNSMNRMAVQALEKMETRKFKAKGKVPREGSCG 253

Mouse   278 ALDTLSSGSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQ-KGNP 341
            .||||||.||||||||||||||||||||||||||||::||||||||:||||||||||||| ||..
Frog   254 GLDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHKRCVDPWLLQNHTCPHCRHNIIEQKKGGH 318

Mouse   342 GAVCVETSNLTRGR---QPRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQN 403
            |.||||.|: .|||   |.||.|||||||||.||..|.||||||||..||||:|:||::|..|.:
Frog   319 GPVCVENSS-NRGRQQQQQRVILPVHYPGRVQRTGPIAAYPTRTSMGPHGNPITVLTVERPLEPD 382

Mouse   404 LYSPQTPTYVRGYPPLHLDHTLAPHRCSLEHRAY--SPA-HPFRRPKFSSRSFSKAACFSQYETM 465
            ||..:|||::.||.|:.|||..:.|.|.|||..|  .|| |.|||.|:|.|.|:...|:||||||
Frog   383 LYPARTPTFLAGYRPVSLDHASSGHHCDLEHPPYPAPPAGHGFRRAKYSGRGFNNGTCYSQYETM 447

Mouse   466 YQHYYFQGLSYPEQE---GQTIPSVTPRGQSRAFPPSGASSLLF---PTMVHVAPPTHVESGSTS 524
            ||||||||||||.|:   |...|.|...|.:.:|  ...:::|:   ||::|:|||:.|.
Frog   448 YQHYYFQGLSYPHQQEVGGSQAPRVVENGHNHSF--HSGNNMLYQPAPTLMHMAPPSSVG----- 505

Mouse   525 SFSCY----HGHRSVCSGYLADCPGSDSSSN---SSGQCRCSSSDSVVDCTEVSNQGVYGSCSTF 582
              |||    |.|||||||||||.|.|||||:   ||.|...|||||::||||.||||||||||||
Frog   506 --SCYLHSQHQHRSVCSGYLADVPCSDSSSSSSASSAQGHASSSDSMLDCTEASNQGVYGSCSTF 568

Mouse   583 RSSLSSDYDPFIYRSRGPAVHLEGSPPPEELPAGHSQSAGRGE---PWLGPASPSGDQLSTCSLE 644
            |||||||:||::||||.||....|..|......|.....||.|   ....|.|||.|:||:||:|
Frog   569 RSSLSSDFDPYVYRSRSPARTGGGDAPGCGGEGGTGSGRGRVECRSHQTFPNSPSRDRLSSCSME 633

Mouse   645 MNYSSNSSLEPRG---PNSSTSEVGLEVSPGAALDLRRTWKGGPEGPSCACCFEPQPFPPGSGIE 706
            ||||||||||.||   .:.:..:..:.:|.|...|.|     ||| ..|.|||:.|...|.|..
Frog   634 MNYSSNSSLERRGAVISSGTVPDASVSISQGGGKDRR-----GPE-KGCTCCFQRQAGDPSSDC- 691

Mouse   707 TSAGGSSLFLGPRLLEDCNPPSGEPQLGSSQGLYGLHSDHYPRTDG---VKYEGLPCCFYEEKQV 768
                 ::|:|||    |.:..||.   .||.|||.:.|....|||.   :.:...|||.|||..
Frog   692 -----TNLYLGP----DPHQTSGP---SSSGGLYSVTSSILHRTDPGTVLGHPSRPCCLYEENH- 743

Mouse   769 AHSAGRGNGCYTEDYSVSVQYTLTEEPPPS-------CYAGPRDLSQRIPIIPEDVDCDLGLPQD 826
                   ..||.|||:||:||.|.|....:       |.||     |.|||||||...|.||  :
Frog   744 -------GSCYNEDYAVSIQYALAEAAAAAAAAAVAGCEAG-----QPIPIIPEDPGYDGGL--E 794

Mouse   827 CHGMHNHSPWGGALSLDVPRLHWSL-GTTREEEQAPCYQAEVQPGCSPEEAGASRASLSSAPQDT 890
            |.|                .:.|.: |...|||...|.:.   |.|:..|
Frog   795 CVG----------------HVSWEMEGEEEEEEVLYCQEG---PCCALAE--------------- 825

Mouse   891 QESHALAAEASGPGSGPGIG 910
             |:.||.......|:|...|
Frog   826 -ETRALCRSTGKEGAGSTTG 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Znrf3	NP_001074393.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		3/13 (23%)
		zf-RING_2	289..331	CDD:290367	38/41 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..669		29/73 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..913		13/56 (23%)
znrf3	NP_001072864.1	ZNRF_3_ecto	74..180	CDD:375639	96/105 (91%)
		RING-H2_ZNRF3	266..309	CDD:319713	39/42 (93%)
		RING-H2 finger (C3H2C3-type)	266..306	CDD:319713	36/39 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..629		16/45 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..673		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..713		12/40 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..853		3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	411	1.000	Domainoid score	I5563
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H46592
Inparanoid	1	1.050	938	1.000	Inparanoid score	I3393
OMA	1	1.010	-	-		QHG40703
OrthoDB	1	1.010	-	-		D138786at33208
OrthoFinder	1	1.000	-	-		FOG0013402
OrthoInspector	1	1.000	-	-		oto196162
Panther	1	1.100	-	-	LDO	PTHR16200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R768
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110