Protein Alignment Znrf3 and znrf3

DIOPT Version :10

• Sequence 1: NP_001074393.1
• Gene: Znrf3 / 407821
• MGIID: 3039616
• Length: 913
• Species: Mus musculus
• Sequence 2: NP_001072864.1
• Gene: znrf3 / 780325
• XenbaseID: XB-GENE-5937936
• Length: 853
• Species: Xenopus tropicalis
• Alignment Length: 930
• Identity: 537/930 - (57%)
• Similarity: 612/930 - (65%)
• Gaps: 127/930 - (13%)

Mouse    18 RLRRGPRGRRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTHTTGLTGRF 82
            |:|.|           |||:...:|.|..||.:.||||||||||||||||:|||.||||.|.|||
 Frog     5 RIRGG-----------LPLVWLWVLLAVAPGESLAKETAFVEVVLFESSPNGDYKTHTTELQGRF 58

Mouse    83 SRAGAMLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRG 147
            |||||.:||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||
 Frog    59 SRAGATISAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPEMDPKPCLTVLGKAKRAVQRG 123

Mouse   148 ATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHLPPRQPTE 212
            |||||||||:||:|::|||||.||||||||||:||.|||||||||||||.|||||||.|||||||
 Frog   124 ATAVIFDVSDNPDAVEQLNQGLEDPLKRPVVYMKGMDAIKLMNIVNKQKGARARIQHRPPRQPTE 188

Mouse   213 YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCG 277
            ||||||||||||||||||||||:|||||||||||||||:|||||||||||||.:|.|..||||||
 Frog   189 YFDMGIFLAFFVVVSLVCLILLIKIKLKQRRSQNSMNRMAVQALEKMETRKFKAKGKVPREGSCG 253

Mouse   278 ALDTLSSGSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQ-KGNP 341
            .||||||.||||||||||||||||||||||||||||::||||||||:||||||||||||| ||..
 Frog   254 GLDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHKRCVDPWLLQNHTCPHCRHNIIEQKKGGH 318

Mouse   342 GAVCVETSNLTRGR---QPRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQN 403
            |.||||.|: .|||   |.||.|||||||||.||..|.||||||||..||||:|:||::|..|.:
 Frog   319 GPVCVENSS-NRGRQQQQQRVILPVHYPGRVQRTGPIAAYPTRTSMGPHGNPITVLTVERPLEPD 382

Mouse   404 LYSPQTPTYVRGYPPLHLDHTLAPHRCSLEHRAY--SPA-HPFRRPKFSSRSFSKAACFSQYETM 465
            ||..:|||::.||.|:.|||..:.|.|.|||..|  .|| |.|||.|:|.|.|:...|:||||||
 Frog   383 LYPARTPTFLAGYRPVSLDHASSGHHCDLEHPPYPAPPAGHGFRRAKYSGRGFNNGTCYSQYETM 447

Mouse   466 YQHYYFQGLSYPEQE---GQTIPSVTPRGQSRAFPPSGASSLLF---PTMVHVAPPTHVESGSTS 524
            ||||||||||||.|:   |...|.|...|.:.:|  ...:::|:   ||::|:|||:.|.
 Frog   448 YQHYYFQGLSYPHQQEVGGSQAPRVVENGHNHSF--HSGNNMLYQPAPTLMHMAPPSSVG----- 505

Mouse   525 SFSCY----HGHRSVCSGYLADCPGSDSSSN---SSGQCRCSSSDSVVDCTEVSNQGVYGSCSTF 582
              |||    |.|||||||||||.|.|||||:   ||.|...|||||::||||.||||||||||||
 Frog   506 --SCYLHSQHQHRSVCSGYLADVPCSDSSSSSSASSAQGHASSSDSMLDCTEASNQGVYGSCSTF 568

Mouse   583 RSSLSSDYDPFIYRSRGPAVHLEGSPPPEELPAGHSQSAGRGE---PWLGPASPSGDQLSTCSLE 644
            |||||||:||::||||.||....|..|......|.....||.|   ....|.|||.|:||:||:|
 Frog   569 RSSLSSDFDPYVYRSRSPARTGGGDAPGCGGEGGTGSGRGRVECRSHQTFPNSPSRDRLSSCSME 633

Mouse   645 MNYSSNSSLEPRG---PNSSTSEVGLEVSPGAALDLRRTWKGGPEGPSCACCFEPQPFPPGSGIE 706
            ||||||||||.||   .:.:..:..:.:|.|...|.|     ||| ..|.|||:.|...|.|..
 Frog   634 MNYSSNSSLERRGAVISSGTVPDASVSISQGGGKDRR-----GPE-KGCTCCFQRQAGDPSSDC- 691

Mouse   707 TSAGGSSLFLGPRLLEDCNPPSGEPQLGSSQGLYGLHSDHYPRTDG---VKYEGLPCCFYEEKQV 768
                 ::|:|||    |.:..||.   .||.|||.:.|....|||.   :.:...|||.|||..
 Frog   692 -----TNLYLGP----DPHQTSGP---SSSGGLYSVTSSILHRTDPGTVLGHPSRPCCLYEENH- 743

Mouse   769 AHSAGRGNGCYTEDYSVSVQYTLTEEPPPS-------CYAGPRDLSQRIPIIPEDVDCDLGLPQD 826
                   ..||.|||:||:||.|.|....:       |.||     |.|||||||...|.||  :
 Frog   744 -------GSCYNEDYAVSIQYALAEAAAAAAAAAVAGCEAG-----QPIPIIPEDPGYDGGL--E 794

Mouse   827 CHGMHNHSPWGGALSLDVPRLHWSL-GTTREEEQAPCYQAEVQPGCSPEEAGASRASLSSAPQDT 890
            |.|                .:.|.: |...|||...|.:.   |.|:..|
 Frog   795 CVG----------------HVSWEMEGEEEEEEVLYCQEG---PCCALAE--------------- 825

Mouse   891 QESHALAAEASGPGSGPGIG 910
             |:.||.......|:|...|
 Frog   826 -ETRALCRSTGKEGAGSTTG 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Znrf3	NP_001074393.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		3/13 (23%)
		ZNRF_3_ecto	98..204	CDD:408039	96/105 (91%)
		RING-H2_ZNRF3	289..333	CDD:319713	40/43 (93%)
		HRD1	<290..383	CDD:227568	76/96 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..669		29/73 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	855..913		13/56 (23%)
znrf3	NP_001072864.1	ZNRF_3_ecto	74..180	CDD:408039	96/105 (91%)
		RING_Ubox	266..309	CDD:473075	39/42 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	583..629		16/45 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	650..673		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	685..713		12/40 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	834..853		3/11 (27%)