DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Znrf3 and Rnf43

DIOPT Version :9

Sequence 1:	NP_001074393.1	Gene:	Znrf3 / 407821	MGIID:	3039616	Length:	913	Species:	Mus musculus
Sequence 2:	XP_006247152.1	Gene:	Rnf43 / 303412	RGDID:	1305204	Length:	802	Species:	Rattus norvegicus

Alignment Length:	951	Identity:	279/951 - (29%)
Similarity:	391/951 - (41%)	Gaps:	282/951 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse    39 GLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTHTTGLTGRFSRAGAMLSAEGEIVQMHPLGL 103
            ||:||||......|::.|.:.|:..:..|:|..   ...|.|.|:....:..|||:::|.|||.|
  Rat    29 GLVLAAAVESERSAEQKAIIRVIPLKMDPTGKL---NLTLEGVFAGVAEVSPAEGKLMQSHPLYL 90

Mouse   104 CNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQG 168
            ||.:|:::| |.|::.:||||.|...|:|||::..||:.|.:|||:||:||::|:..|.:||.|
  Rat    91 CNASDDDNL-EPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRSAAEQLQQ- 153

Mouse   169 SEDP--LKRPVVYVKGADAIKLMNIVNKQKVARARIQHLPPRQPTEYFDMGIFLAFFVVVSLVCL 231
               |  |.:|||.:.|:||.|||..|.|.:.|...|:...|.....| |:.|.|.....|.::.|
  Rat   154 ---PLGLTKPVVLIWGSDAEKLMEFVYKNRKAYVWIELKEPPAWANY-DVWILLTVVGTVFVIIL 214

Mouse   232 ILLVKIKLKQRRSQ-NSMNRLAVQALEKMETRKFNSKSKGRR-----EGSCGALDTLSSGSTSDC 290
            ..:::|:.:...|: :.:.:...:|:.::.||::.:..:..|     .||       ||.|...|
  Rat   215 ASVLRIRCRPHPSRPDPLQQRTARAISQLATRRYQASCRRARAEWPDSGS-------SSSSAPVC 272

Mouse   291 AICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPGAVCVETSNLTRGR 355
            |||||::.:|:|||||.|.|.|||.||||||.||.|||.|..||:|......|:....|....||
  Rat   273 AICLEEFTEGQELRVISCLHEFHRTCVDPWLHQHRTCPLCMFNIVEGDSFSQALGASPSYQEPGR 337

Mouse   356 QPRVTLPVHYPGRVHRTNAIP-AY---PTRTSMDSHGNPVTLLTMDRHGEQNLYSPQTPTYVRGY 416
              |:.|...:||..|  ..:| ||   |:|.|:.....|...|           ..|.|:....:
  Rat   338 --RLHLIRQHPGHAH--YHLPSAYLLGPSRNSVAQTPRPRPFL-----------PSQEPSMGSRH 387

Mouse   417 PPL-HLDHTLAPHRCSLEHRAYSPAHPFRR---PKFSSRSFSKAACFSQYETMYQHYYFQGLSYP 477
            ..| ...|..||.  ..:|.|.||.||:.:   |       ::..|.||:
  Rat   388 QRLPRASHLRAPE--EQQHLAVSPGHPYAQGWGP-------NRLRCTSQH--------------- 428

Mouse   478 EQEGQTIPSVTPRGQSRAFPPSGASSLLFPTMVHVAPPTHVESGSTSSFSCYHGHRSVC---SGY 539
                   |:..|....||.|                   |..|||..|:         |   |||
  Rat   429 -------PNACPVALRRARP-------------------HESSGSGESY---------CTERSGY 458

Mouse   540 LADCPGSDSSSNSSGQCRCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRS-----RG 599
            |||.|.|||   |||.|..|||||||:||::|.|||:||.||||||||||:||.:|.|     :|
  Rat   459 LADGPASDS---SSGPCHGSSSDSVVNCTDISLQGVHGSSSTFRSSLSSDFDPLVYCSPEGALQG 520

Mouse   600 PAVHLEGSPPPEEL----PAG------------------------HSQSAG--RGEPWLGPASPS 634
            ..|....:..|..|    |.|                        ||:..|  .|.|...||
  Rat   521 KEVQPSMTSRPRSLDSVVPTGETQVSSHIHYHRHRHHHYKKQFQWHSRKPGLETGVPQSRPA--- 582

Mouse   635 GDQLSTCSLEMNYSSNSSLEPRGPNSSTSEVGLEVSPGAALDLRRTWKGGPEGPSCACCFEPQPF 699
                         :|::.|||..|:...:      :|..|:.                ...|.|.
  Rat   583 -------------ASHTQLEPSLPDQQLT------TPNPAVS----------------SMLPNPQ 612

Mouse   700 PPGSGIETSAGGSSLFLGPRLLEDCNP-PSGEPQLGSSQGLYGLHSDHYPRTDGVKY-------- 755
            .|.:..|.:         |.|.|..:| ||..|      .|..|...:.|    |:|
  Rat   613 RPRALTEPA---------PGLAEAVSPSPSPNP------SLLNLQKSNLP----VRYPQRKRRGG 658

Mouse   756 --EGLPCCFYEEKQVAHSAGRGNGC-YTEDYSVSVQY------------------TLTEEPPPSC 799
              |.||....::..| |:|     | ....||.|:.|                  .|..:.|..|
  Rat   659 PSEALPTSQPQDLTV-HTA-----CPVPPHYSPSLAYPWPPEVHPLIFRPPGLDRRLLHDVPGPC 717

Mouse   800 YAGPRD----LSQRIPIIPEDVDCDLGLPQDCHGMHNHSPWGGALSLDVPRLHWSLGTTREEEQA 860
            |:..:.    |:.|.|:.|            |.....||.|    |.|.|          |:.:.
  Rat   718 YSSSQPVWLYLNPRQPLGP------------CLPGEGHSKW----SFDTP----------EDRRC 756

Mouse   861 P---CYQAEVQPG-CSPEE--------AGASRASLSSAPQD 889
            |   |.....||| ||.::        :|..||..:|...|
  Rat   757 PYSHCQVLPAQPGECSGKQVFWEKETISGCWRAGENSQGVD 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Znrf3	NP_001074393.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		zf-RING_2	289..331	CDD:290367	28/41 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..669		17/97 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..913		13/47 (28%)
Rnf43	XP_006247152.1	ZNRF_3_ecto	85..187	CDD:408039	48/106 (45%)
		RING-H2_RNF43	270..316	CDD:319712	29/45 (64%)
		dnaA	598..>743	CDD:237605	38/203 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138786at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920