DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18048 and trm13

DIOPT Version :9

Sequence 1:	NP_649646.3	Gene:	CG18048 / 40782	FlyBaseID:	FBgn0037435	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_593914.2	Gene:	trm13 / 2542398	PomBaseID:	SPAC1805.03c	Length:	368	Species:	Schizosaccharomyces pombe

Alignment Length:	382	Identity:	134/382 - (35%)
Similarity:	204/382 - (53%)	Gaps:	52/382 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ERIPCPLDHKHTVFKRKLAKHLTICNARDQESSLPYIVKGVNSGDNLKETDEDLNKFNQIKLHEL 131
            ::||||.|||||:.:.:|..||..||||..|.:.||..|.:|.     .|..|.::.:..::.:|
pombe    14 KQIPCPYDHKHTIVRHRLEYHLKRCNARPVERTDPYYKKDINI-----STSTDASESSSFEIVDL 73

  Fly   132 ADEEFYSLIDKVKNLYDKHINSSI---QELQLEHESLK---EELSRKDYGQETLRQLTQTTSLLG 190
            :.||    :.|...|::: |:.|:   |:..|.|.::.   ||.::|       :...|..||||
pombe    74 SKEE----LSKWICLFNR-ISDSLPTPQKKVLFHPAMNARLEEGTKK-------KHAIQQASLLG 126

  Fly   191 ILEHDHQLMDHTS-YIEFGAGKGQLAYFLATVLQEQKLSHSQVVLIDRMSLRHKKDNKLANREV- 253
            .:|..|...:..| |.|||||:.:|:.::....|::.:    .:||||.|.|.|.|:::....:
pombe   127 HMEKLHYFDNQGSIYYEFGAGRAELSRYVQHCSQQENV----YILIDRDSNRTKHDSRILKDSIK 187

  Fly   254 -------VQRIRADIADLKLSAL-PELKKTQRTV-AFSKHLCGAATDLTLRCILGDGNASSDYVL 309
                   :.|.:.||.||||... .|.:.:.:.| |:|||||||||||||.|:   .::..:.::
pombe   188 NNWPEPKIIRCKIDIKDLKLDFFASEFRNSGKPVFAYSKHLCGAATDLTLNCL---KSSPPNALV 249

  Fly   310 IALCCHHRCSWR--SYVGRKFLQEAGI-GPREFVILTKMVSWAVCGTGLSRERRKAMESADFQLT 371
            |||||||.|.||  |...|:.|...|| .|:||.||.:|..|||   ...||...|...||
pombe   250 IALCCHHHCRWRTLSTFAREQLSHWGISNPQEFQILRQMTGWAV---NSLREHMHASGGAD---- 307

  Fly   372 ETNTQRLTRQEREQIGQQCKRVLDYGRLEHLRSHGYQAELKFYVPRDVTLENVVLLA 428
             ::...|:.:||.:||.:||.:::|.|.......||::.|.:||..:.|||||.|:|
pombe   308 -SHISGLSHEERVKIGLKCKHIINYMRKLECEKMGYESSLVYYVGEETTLENVALIA 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18048	NP_649646.3	zf-TRM13_CCCH	20..44	CDD:288558
		zf-U11-48K	69..92	CDD:283028	12/22 (55%)
		TRM13	183..429	CDD:282990	98/260 (38%)
trm13	NP_593914.2	zf-U11-48K	16..39	CDD:283028	12/22 (55%)
trm13	NP_593914.2	TRM13	119..364	CDD:282990	98/260 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	143	1.000	Domainoid score	I1176
eggNOG	1	0.900	-	-		E1_KOG2811
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6875
Inparanoid	1	1.050	185	1.000	Inparanoid score	I1093
OMA	1	1.010	-	-		QHG54880
OrthoFinder	1	1.000	-	-		FOG0005014
OrthoInspector	1	1.000	-	-		oto101339
orthoMCL	1	0.900	-	-		OOG6_103381
Panther	1	1.100	-	-	LDO	PTHR12998
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1546
SonicParanoid	1	1.000	-	-		X3545
TreeFam	1	0.960	-	-
	14	13.860