DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tlk2 and Tlk

DIOPT Version :9

Sequence 1:	NP_001103887.1	Gene:	tlk2 / 407732	ZFINID:	ZDB-GENE-060623-36	Length:	697	Species:	Danio rerio
Sequence 2:	NP_001138153.1	Gene:	Tlk / 318206	FlyBaseID:	FBgn0283657	Length:	1489	Species:	Drosophila melanogaster

Alignment Length:	944	Identity:	381/944 - (40%)
Similarity:	482/944 - (51%)	Gaps:	290/944 - (30%)

- Green bases have known domain annotations that are detailed below.

Zfish    22 GVGVAKGSGHNESSNQSLCSVGSLSDKELETPEKKSNDQRTRKRKGDPFDSQGK-GGGRGHKISD 85
            ||||..|:|.|.:..:     ||.:....::|......|...:::|....:.|. ||..|:::.
  Fly   567 GVGVPGGAGGNTAGLR-----GSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSAGGSAGNQVQ- 625

Zfish    86 YFEFAGGSGTGTSPARGIPPVARSSPQHSLSN--------------------------------- 117
                     ..||.|..:.|.|  |||...|.
  Fly   626 ---------VQTSSAYALYPPA--SPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQ 679

Zfish   118 --PP-------------AAVQQGSP---------------------SSISSVNTDHSHTSTS--- 143
              ||             |::||.:|                     :|.:||...|.|...|
  Fly   680 MVPPHVVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGV 744

Zfish   144 ----------------------------HKPASIHTQHRASQSELTMEKLAALESSKSSDLEKKE 180
                                        ..||:|.|..:|:|:|:::.:|    ..:.::.|..:
  Fly   745 VGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLHEL----QEREAEHESGK 805

Zfish   181 GRIDDLLRVNCDLRRQIDEQQKMLERCKERLNKCVTMSKKLLIEKSKQEKIACREKSMQDRLRLG 245
            .::|::.|::.:.:.||...||.:::.|..:.||:.:.||||.|||..||...|:|.||:|||||
  Fly   806 VKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLG 870

Zfish   246 HFTTVRHGASFTEQWTDGYAFQNLVKQQERVNGQREEIERQRKLLMKKKPPSASQTPPPNLEPNK 310
            .|.|.|.||:|.|.||||||||.|.::||.:..:||||:||:|.||||:|..:.:....|...|.
  Fly   871 QFVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNNNSNQNN 935

Zfish   311 RK--------------------------------------------------------------- 312
            ::
  Fly   936 QQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGG 1000

Zfish   313 ----------------SKSNGAENEMLSL------------------------------------ 325
                            |:||..:.....|
  Fly  1001 GGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGND 1065

Zfish   326 ----------------------AEYHEQEEIFKLRLGHLKKEEAEIQVELERLERVRNLHIRELK 368
                                  .||:|.:||.|||...||||:|::|:|:|:|||.|||||||||
  Fly  1066 SGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELK 1130

Zfish   369 RIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENY 433
            ||.|||.|:|.:||.||||||||.|||:||||||:|||||.||||||.|:|||||:|:::||.||
  Fly  1131 RILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANY 1195

Zfish   434 HKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIM 498
            .|||.|||.|||.|||||:|||||.|.:|.:|||||||||:|:||||||||||.:.|:|||||||
  Fly  1196 IKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIM 1260

Zfish   499 QVVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDNYGVD-GMELTSQG 562
            |||:||||||||:||:||||||||||||..|..|||||||||||||:|||:||..| ||:|||||
  Fly  1261 QVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQG 1325

Zfish   563 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGKKPFGHNQSQQDILQENTILKATEV 627
            ||||||||||||||||.|||||:|||||||||||||||||||||||||||..||:||||||||||
  Fly  1326 AGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEV 1390

Zfish   628 QFPPKPGVSPEAKAFIRRCLVYRKEDRIDVHQLASDPYLLPHIRK-------------------- 672
            ||..||.||.|||:|||.||.||||||:||..||...|:.|.|.|
  Fly  1391 QFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQQQQQ 1455

Zfish   673 ----------SVAATGNSSMAVASTSNSSNSSAS 696
                      ...:||.:|.:.....|.:.||:|
  Fly  1456 QQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS 1489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tlk2	NP_001103887.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..159		40/234 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..316		9/106 (8%)
		PKc_like	381..684	CDD:304357	233/333 (70%)
		S_TKc	399..666	CDD:214567	211/267 (79%)
Tlk	NP_001138153.1	S_TKc	1161..1429	CDD:214567	211/267 (79%)
Tlk	NP_001138153.1	STKc_TLK	1161..1428	CDD:270892	211/266 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596661
Domainoid	1	1.000	461	1.000	Domainoid score	I463
eggNOG	1	0.900	-	-		E1_KOG1151
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4993
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001851
OrthoInspector	1	1.000	-	-		otm25594
orthoMCL	1	0.900	-	-		OOG6_101432
Panther	1	1.100	-	-	LDO	PTHR22974
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3972
SonicParanoid	1	1.000	-	-		X1213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.730