Protein Alignment NPFR and CCKAR

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_000721.1
• Gene: CCKAR / 886
• HGNCID: 1570
• Length: 428
• Species: Homo sapiens
• Alignment Length: 433
• Identity: 108/433 - (24%)
• Similarity: 176/433 - (40%)
• Gaps: 125/433 - (28%)

  Fly    90 ISMYGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPY 154
            |.:|.::.:...||||||:..:||...|||..|:|:|:||:|||:|||..||..|:..|.|.:.:
Human    45 ILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIF 109

  Fly   155 GSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYPTRDSLQFV--GAVTILAGIWALALLL 217
            ||.  :|||........:.|||.::.||:.:||..|..|.:..:...  .|:.::|..|.|:..:
Human   110 GSA--VCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTI 172

  Fly   218 ASPLFVYKELI-----NTDTPALLQQIGLQDTIPYCIEDWPSRNGRFYYSIFSLCVQYLVPILIV 277
            .:|..:|..|:     |..|..:.:.:...|.:.   :.|.:         |.|.:.:|:|.:::
Human   173 MTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQ---QSWHT---------FLLLILFLIPGIVM 225

  Fly   278 SVAYFGIYNKLKSRITVVAVQASSAQ--------------------------RKVE--------- 307
            .|||..|..:|...|...|.|..||:                          ||:|
Human   226 MVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSS 290

  Fly   308 -RGRRM------------KRTNCLLISIAIIFGVSWLPL---NFFNLY--ADMER----SPVTQS 350
             |..|:            ||...:||.|.::|.:.|:|:   |.:..|  |..||    :|::..
Human   291 SRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFI 355

  Fly   351 MLVRYAICHMIGMSSACSNPLLYGWLNDNFRKEFQELLCRCSDTNVALNGHTTGCNVQAAARRRR 415
            :|:.|        :|:|.||::|.::|..||..|......|.:.
Human   356 LLLSY--------TSSCVNPIIYCFMNKRFRLGFMATFPCCPNP--------------------- 391

  Fly   416 KLGAELSKGELKLLGPGGAQSGTA----GGEGGLAATDFMTGH 454
                          ||.||:....    ||..|.:.:.|...|
Human   392 --------------GPPGARGEVGEEEEGGTTGASLSRFSYSH 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	97/357 (27%)
		TM helix 1	88..114	CDD:320331	9/23 (39%)
		TM helix 2	121..146	CDD:320331	14/24 (58%)
		TM helix 3	161..191	CDD:320331	10/29 (34%)
		TM helix 4	202..223	CDD:320331	5/20 (25%)
		TM helix 5	258..287	CDD:320331	8/28 (29%)
		TM helix 6	310..340	CDD:320331	11/46 (24%)
		TM helix 7	352..377	CDD:320331	7/24 (29%)
CCKAR	NP_000721.1	CholecysA-Rec_N	1..47	CDD:462713	1/1 (100%)
		7tm_GPCRs	42..381	CDD:475119	97/357 (27%)
		TM helix 1	44..68	CDD:410628	8/22 (36%)
		TM helix 2	77..99	CDD:410628	13/21 (62%)
		TM helix 3	115..137	CDD:410628	7/21 (33%)
		TM helix 4	160..176	CDD:410628	3/15 (20%)
		TM helix 5	207..230	CDD:410628	7/31 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	248..272		2/23 (9%)
		TM helix 6	312..334	CDD:410628	6/21 (29%)
		TM helix 7	349..374	CDD:410628	8/32 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..428		7/27 (26%)