DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NPFR and QRFPR

DIOPT Version :9

Sequence 1:	NP_001246947.1	Gene:	NPFR / 40754	FlyBaseID:	FBgn0037408	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_937822.2	Gene:	QRFPR / 84109	HGNCID:	15565	Length:	431	Species:	Homo sapiens

Alignment Length:	411	Identity:	111/411 - (27%)
Similarity:	204/411 - (49%)	Gaps:	53/411 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VHALNTTAINTS----DLNETGSR-----PLDPVLIDRFLSNRAVDSPWYHMLISMYGVLIVFGA 101
            :.|||.|....|    |.|.|..:     .|.|::....|..||      .:.:.:.||||...|
Human     1 MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRA------KLALVLTGVLIFALA 59

  Fly   102 L-GNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIA 165
            | ||.||...|.|...|||..|:||.:||:||||:....:|:|:::.:|..|..|  :.:||.:.
Human    60 LFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGG--AFICKMVP 122

  Fly   166 MLQALCIFVSTISITAIAFDRYQVIVYPTRDSLQFVG--AVTILAGIWALALLLASPLFVYKELI 228
            .:|:..:....:::|.||.:|:|.:|:|.:...|:..  |.|:|..:|.:|:::.||::
Human   123 FVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMW------ 181

  Fly   229 NTDTPALLQQIGLQDTIPY------CIEDWPSRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNK 287
                  .:||:.::....|      |:|:|.|...:..|:.|.|.:.:|:|::::.:.|..|..:
Human   182 ------HVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYE 240

  Fly   288 L--KSRITVVAVQASSAQRKVER-GRRMKRTNCLLISIAIIFGVSWLPLNFFNL---YADMER-- 344
            |  |.|:...:|..:...:::.: .|:.||...:::::..:|.|.|.|.:..::   |::.|:
Human   241 LWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEY 305

  Fly   345 SPVTQSMLVRYAICHMIGMSSACSNPLLYGWLNDNFRKEFQELLCRCSDTNVALNGHTTGCNVQA 409
            ..||..|:  :||..:||.|::..||::|.::|:||:|.....:|.|............|.:...
Human   306 DDVTIKMI--FAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGIT 368

  Fly   410 AARRRRKLG-----AELSKGE 425
            ..|::.|..     .|.:|||
Human   369 MMRKKAKFSLRENPVEETKGE 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tm_4	98..>195	CDD:304433	35/97 (36%)
NPFR	NP_001246947.1	7tm_1	103..373	CDD:278431	78/285 (27%)
QRFPR	NP_937822.2	7tm_1	62..332	CDD:278431	78/285 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3897
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940