Protein Alignment NPFR and Npffr2

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_076470.1
• Gene: Npffr2 / 78964
• RGDID: 620168
• Length: 417
• Species: Rattus norvegicus
• Alignment Length: 408
• Identity: 108/408 - (26%)
• Similarity: 184/408 - (45%)
• Gaps: 73/408 - (17%)

  Fly    58 DLNETGSRPLDPVLIDRFLSNRAVDSPWYH------------------MLISMYGVLIVFGALGN 104
            |.|.:||       .|...|......|||.                  :.||.|.::.....:||
  Rat     6 DSNSSGS-------WDHIWSGNDTQHPWYSDINITYMNYYLHQPHVTAVFISSYFLIFFLCMVGN 63

  Fly   105 TLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQA 169
            |:|...|||...|.|..|.||.||||||||:.:..||:||::.:...||:||.  :||...::|.
  Rat    64 TVVCFVVIRNRYMHTVTNFFIFNLAISDLLVGIFCMPITLLDNIIAGWPFGSS--MCKISGLVQG 126

  Fly   170 LCIFVSTISITAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALALLLASP----LFVYKELINT 230
            :.:..|..::.|||.||::.:|||.:..|....|..::..||.||:.:.:|    |.|.:|....
  Rat   127 ISVAASVFTLVAIAVDRFRCVVYPFKPKLTVKTAFVMIVIIWGLAITIMTPSAIMLHVQEEKYYR 191

  Fly   231 DTPALLQQIGLQDTIPYCIEDWPSRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKLKSRITVV 295
               ..|.......|:.:|.||||::..|..|:.......||.|:.::.:    :|.::.:.:...
  Rat   192 ---VRLSSHNKTSTVYWCREDWPNQEMRRIYTTVLFATIYLAPLSLIVI----MYARIGASLFKT 249

  Fly   296 AVQASSAQRKVER---GRRMKRTNCLLISIAIIFGVSWLP---LNFFNLYADMERSPVTQSMLVR 354
            :..::..|| :|:   .::.::...:|:::|::|.:||||   |...:.|||:..:.:....:..
  Rat   250 SAHSTGKQR-LEQWHVSKKKQKVIKMLLTVALLFILSWLPLWTLMMLSDYADLSPNKLRVINIYV 313

  Fly   355 YAICHMIGMSSACSNPLLYGWLNDNFRKEFQELLCRC-------------SDTNVALN------- 399
            |...|.:...::..||::||:.|:|||..||:....|             :..|:.:|
  Rat   314 YPFAHWLAFCNSSVNPIIYGFFNENFRSGFQDAFQFCQKKVKPQEAYGLRAKRNLDINTSGLLVH 378

  Fly   400 --------GHTTGCNVQA 409
                    |...||...|
  Rat   379 EPASQNPSGENLGCRKSA 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	90/305 (30%)
		TM helix 1	88..114	CDD:320331	9/25 (36%)
		TM helix 2	121..146	CDD:320331	15/24 (63%)
		TM helix 3	161..191	CDD:320331	9/29 (31%)
		TM helix 4	202..223	CDD:320331	7/24 (29%)
		TM helix 5	258..287	CDD:320331	6/28 (21%)
		TM helix 6	310..340	CDD:320331	8/32 (25%)
		TM helix 7	352..377	CDD:320331	6/24 (25%)
Npffr2	NP_076470.1	7tm_GPCRs	46..343	CDD:475119	90/306 (29%)
		TM helix 1	48..72	CDD:410628	8/23 (35%)
		TM helix 2	81..103	CDD:410628	13/21 (62%)
		TM helix 3	119..141	CDD:410628	5/21 (24%)
		TM helix 4	162..178	CDD:410628	4/15 (27%)
		TM helix 5	217..240	CDD:410628	4/26 (15%)
		TM helix 6	272..294	CDD:410628	8/21 (38%)
		TM helix 7	311..336	CDD:410628	6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..417		4/19 (21%)