Protein Alignment NPFR and SSTR3

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001042.1
• Gene: SSTR3 / 6753
• HGNCID: 11332
• Length: 418
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 110/456 - (24%)
• Similarity: 199/456 - (43%)
• Gaps: 76/456 - (16%)

  Fly    49 LNTTAINTSDLNETGSRPLDPVLIDRFLSNRAVDSPWYHMLIS------MYGVLIVFGALGNTLV 107
            |:.::::|:...|..|....|   |..|.|.:.......:.:|      :|.|:.|.|.|||:||
Human     4 LHPSSVSTTSEPENASSAWPP---DATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLV 65

  Fly   108 VIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCI 172
            :..|:|.....:..|::|||||::|.|. ::.:|....:....|||:|  |::|:.:..:..:..
Human    66 IYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFG--SLMCRLVMAVDGINQ 127

  Fly   173 FVSTISITAIAFDRYQVIVYPTRDSLQFVGAV--TILAGIWALALLLASPLFVYKELINTDTPAL 235
            |.|...:|.::.|||..:|:|||.:......|  |:.|.:|..:.::..|:.|:.
Human   128 FTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFS---------- 182

  Fly   236 LQQIGLQDTIPYCIEDWPS-----RNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKLKSRITVV 295
                |:...:..|...||.     |.|   :.|::..:.:..|:|::.:.|..|..|::|  ...
Human   183 ----GVPRGMSTCHMQWPEPAAAWRAG---FIIYTAALGFFGPLLVICLCYLLIVVKVRS--AGR 238

  Fly   296 AVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLP---LNFFNLYADMERSPVTQSMLVRYAI 357
            .|.|.|.||:....||:.|   :::::..:|.:.|:|   ||..|:...:...|....:   |.:
Human   239 RVWAPSCQRRRRSERRVTR---MVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGL---YFL 297

  Fly   358 CHMIGMSSACSNPLLYGWLNDNFRKEFQELLCRCSDTNVALNGHTTGCNVQAAARRRRKLGAELS 422
            ...:..:::|:||:|||:|:..|::.|:.:|.|.|                   ||.|.....:.
Human   298 VVALPYANSCANPILYGFLSYRFKQGFRRVLLRPS-------------------RRVRSQEPTVG 343

  Fly   423 KGELKLLGPGGAQSGTAGGEGGLAATDFMTGHHEGGLRSAITESVALTDHNP---VPSEVTKLMP 484
            ..|.........:.|....|||       .|....|..|.||:........|   |.|:..:|:|
Human   344 PPEKTEEEDEEEEDGEESREGG-------KGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLP 401

  Fly   485 R 485
            :
Human   402 Q 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	80/311 (26%)
		TM helix 1	88..114	CDD:320331	11/31 (35%)
		TM helix 2	121..146	CDD:320331	9/24 (38%)
		TM helix 3	161..191	CDD:320331	7/29 (24%)
		TM helix 4	202..223	CDD:320331	5/22 (23%)
		TM helix 5	258..287	CDD:320331	5/28 (18%)
		TM helix 6	310..340	CDD:320331	9/32 (28%)
		TM helix 7	352..377	CDD:320331	7/24 (29%)
SSTR3	NP_001042.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		4/16 (25%)
		7tm_GPCRs	45..324	CDD:475119	79/306 (26%)
		TM helix 1	47..71	CDD:410628	10/23 (43%)
		TM helix 2	80..101	CDD:410628	9/21 (43%)
		TM helix 3	117..139	CDD:410628	3/21 (14%)
		TM helix 4	162..178	CDD:410628	3/15 (20%)
		TM helix 5	204..227	CDD:410628	4/25 (16%)
		TM helix 6	256..278	CDD:410628	5/24 (21%)
		TM helix 7	292..317	CDD:410628	7/27 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..418		16/75 (21%)