Protein Alignment NPFR and npffr1l1

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001165167.1
• Gene: npffr1l1 / 559950
• ZFINID: ZDB-GENE-091118-18
• Length: 398
• Species: Danio rerio
• Alignment Length: 433
• Identity: 125/433 - (28%)
• Similarity: 193/433 - (44%)
• Gaps: 62/433 - (14%)

  Fly    49 LNTTAINTSDLNETGSRPLDPVLIDRFLSNRAVDSPWYHMLISMYGVLIVFGALGNTLVVIAVIR 113
            ||.:|.|.|..|.|        |:..::.:..:...:    |..|.::::...:||.||.:.|||
Zfish     6 LNHSAANLSWQNCT--------LLPYYIHSAGMAVSY----ILSYLLVLLLCVVGNGLVCLVVIR 58

  Fly   114 KPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTIS 178
            ...||:..||||||||:||||:.:..:|.||::.|...||:.  .|.|....::|.:.:..|..:
Zfish    59 NRNMRSVTNLFILNLAVSDLLVGIFCVPTTLIDSLISGWPFS--QITCTMSNLVQGMSVSASVFT 121

  Fly   179 ITAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALALLLASPLFVYKELINTDTPALLQQIGLQD 243
            :.|||.||:..||||....|:.|.|:..:..||.||..:..|......:|:.|...::|    .|
Zfish   122 LVAIAVDRFTGIVYPFHHRLRPVTALFAIVFIWLLAFAIIFPSAATLTVIHLDDMYMVQ----ND 182

  Fly   244 TI-P--YCIEDWPSRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKLKSRITVVAVQASSAQRK 305
            .| |  .|.||||..:.|..|:.......||.|:.::|:.|..|..||.|.:          |..
Zfish   183 QIYPLFVCFEDWPRADMRRVYTTVIFVHVYLAPLGLISIMYGCIAAKLSSNL----------QEN 237

  Fly   306 VERGRRMKRTNCLLISIAIIFGVSWLPLNFFNL---YADMERSPVTQSMLVRYAICHMIGMSSAC 367
            ..|.||..:...:||.:|::|.||||||....|   |.|::|..:.......:.:.|.:...::.
Zfish   238 RLRSRRRMKVIKMLIMVAVLFMVSWLPLWTLMLLTDYQDLDRQQIDFLSSYLFPVAHWLAFFNSG 302

  Fly   368 SNPLLYGWLNDNFRKEFQ-ELLCR-CSDTNVALNGHTTGCNVQAAARRRRKLGAELSKGELKLLG 430
            .||::||:.|:|||:.|| .:.|. ||                       .:.:|:......|..
Zfish   303 VNPIIYGFFNENFRRGFQAAVACGFCS-----------------------SVASEMRHTHFVLPP 344

  Fly   431 PGGAQSGTAGGEGGLAATDFMTGHHEGGLRSAITESVALTDHN 473
            |.....|:.|...|.....|....|  |....| :.:.|.|.|
Zfish   345 PNKVSDGSRGVTSGRKERCFPVIPH--GAAHGI-QGILLEDMN 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	99/301 (33%)
		TM helix 1	88..114	CDD:320331	8/25 (32%)
		TM helix 2	121..146	CDD:320331	15/24 (63%)
		TM helix 3	161..191	CDD:320331	8/29 (28%)
		TM helix 4	202..223	CDD:320331	6/20 (30%)
		TM helix 5	258..287	CDD:320331	8/28 (29%)
		TM helix 6	310..340	CDD:320331	13/32 (41%)
		TM helix 7	352..377	CDD:320331	5/24 (21%)
npffr1l1	NP_001165167.1	7tm_GPCRs	32..319	CDD:475119	99/306 (32%)
		TM helix 1	34..58	CDD:320647	7/27 (26%)
		TM helix 2	67..89	CDD:320647	13/21 (62%)
		TM helix 3	105..127	CDD:320647	4/21 (19%)
		TM helix 4	148..164	CDD:320647	4/15 (27%)
		TM helix 5	201..224	CDD:320647	5/22 (23%)
		TM helix 6	248..270	CDD:320647	10/21 (48%)
		TM helix 7	287..312	CDD:320647	5/24 (21%)