Protein Alignment NPFR and NPY4R

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_005963.4
• Gene: NPY4R / 5540
• HGNCID: 9329
• Length: 375
• Species: Homo sapiens
• Alignment Length: 405
• Identity: 122/405 - (30%)
• Similarity: 195/405 - (48%)
• Gaps: 63/405 - (15%)

  Fly    54 INTSDL----------NETGSRPL-DPVLIDRFLSNRAVDSPWYHMLISMYGVLIVFGALGNTLV 107
            :|||.|          .|..|:|| .|........: :||...:  :::.|.:..|.|.|||..:
Human     1 MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQD-SVDVMVF--IVTSYSIETVVGVLGNLCL 62

  Fly   108 VIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCI 172
            :...:|:.......||.|.|||.||.|:||:..|||.:..:..||.:|  ..|||..|.:|.:.:
Human    63 MCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFG--ETLCKMSAFIQCMSV 125

  Fly   173 FVSTISITAIAFDRYQVIVYPT--RDSLQ--FVGAVTILAGIWALALLLASPLF---VYKELINT 230
            .||.:|:..:|.:|:|:|:.||  :.|:.  ::|.|.    ||.:|.:|:.|..   :.:.:.:.
Human   126 TVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVL----IWVIACVLSLPFLANSILENVFHK 186

  Fly   231 DTPALLQQIGLQDTIPYCIEDWPSRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKLKSRITVV 295
            :....|:  .|.|.: .|.|.||..:.|..|:.|.|..||.:|:..:.|.|..||..|:.:..|.
Human   187 NHSKALE--FLADKV-VCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRCLQRQGRVF 248

  Fly   296 AVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADM--ERSPVTQSMLVRYAIC 358
            .....|.     |...||:.|.:|:.:.:.|.|.||||:.||...|.  |..|:....|: :.:|
Human   249 HKGTYSL-----RAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHGNLI-FLVC 307

  Fly   359 HMIGMSSACSNPLLYGWLNDNFRKEFQELLCRCSDT-------NVALNG-HTTGCNVQAAARRRR 415
            |::.|:|.|.||.:||:||.||:||.:.|:..|..:       ::.|:. ||
Human   308 HLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHT------------- 359

  Fly   416 KLGAELSKGELKLLG 430
                |:|||.|:|.|
Human   360 ----EVSKGSLRLSG 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	98/304 (32%)
		TM helix 1	88..114	CDD:320331	6/25 (24%)
		TM helix 2	121..146	CDD:320331	14/24 (58%)
		TM helix 3	161..191	CDD:320331	10/29 (34%)
		TM helix 4	202..223	CDD:320331	7/23 (30%)
		TM helix 5	258..287	CDD:320331	11/28 (39%)
		TM helix 6	310..340	CDD:320331	12/29 (41%)
		TM helix 7	352..377	CDD:320331	10/24 (42%)
NPY4R	NP_005963.4	7tmA_NPY4R	42..333	CDD:320519	98/307 (32%)
		TM helix 1	43..69	CDD:320519	6/27 (22%)
		TM helix 2	76..101	CDD:320519	14/24 (58%)
		TM helix 3	114..144	CDD:320519	10/29 (34%)
		TM helix 4	155..176	CDD:320519	7/24 (29%)
		TM helix 5	211..240	CDD:320519	11/28 (39%)
		TM helix 6	258..288	CDD:320519	12/29 (41%)
		TM helix 7	301..326	CDD:320519	10/25 (40%)