Protein Alignment NPFR and OPRM1

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001138751.1
• Gene: OPRM1 / 4988
• HGNCID: 8156
• Length: 493
• Species: Homo sapiens
• Alignment Length: 365
• Identity: 93/365 - (25%)
• Similarity: 174/365 - (47%)
• Gaps: 46/365 - (12%)

  Fly    54 INTSDLNETGSRPLDPVLIDRFLSNR-----AVDSPWYHM-----LISMYGVLIVFGALGNTLVV 108
            :|.|.|:...|.|..|...|  |..|     ...||  .|     ::::|.::.|.|..||.||:
Human   125 VNLSHLDGNLSDPCGPNRTD--LGGRDSLCPPTGSP--SMITAITIMALYSIVCVVGLFGNFLVM 185

  Fly   109 IAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIF 173
            ..::|...|:||.|::|.|||::| .|...|:|...:..|...||:|  :||||.:..:....:|
Human   186 YVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFG--TILCKIVISIDYYNMF 247

  Fly   174 VSTISITAIAFDRYQVIVYPTRDSLQF---VGAVTILAGIWALALLLASPLFVYKELINTDTPAL 235
            .|..::..::.|||..:.:|.: :|.|   ..|..|....|.|:..:..|:...       ....
Human   248 TSIFTLCTMSVDRYIAVCHPVK-ALDFRTPRNAKIINVCNWILSSAIGLPVMFM-------ATTK 304

  Fly   236 LQQIGLQDTIPYCIEDWPSRNGRFYYSIFSLCV---QYLVPILIVSVAYFGIYNKLKSRITVVAV 297
            .:|..:..|:.:....|      ::.::..:||   .:::|:||::|.|..:..:|||      |
Human   305 YRQGSIDCTLTFSHPTW------YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKS------V 357

  Fly   298 QASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERSPVTQSMLVRYAICHMIG 362
            :..|..:  |:.|.::|...:::.:..:|.|.|.|::.:.:...:...|.|....|.:..|..:|
Human   358 RMLSGSK--EKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALG 420

  Fly   363 MSSACSNPLLYGWLNDNFRKEFQELLCRCSDTNVALNGHT 402
            .:::|.||:||.:|::||::.|:| .|..:.:|:.....|
Human   421 YTNSCLNPVLYAFLDENFKRCFRE-FCIPTSSNIEQQNST 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	77/306 (25%)
		TM helix 1	88..114	CDD:320331	8/30 (27%)
		TM helix 2	121..146	CDD:320331	9/24 (38%)
		TM helix 3	161..191	CDD:320331	7/29 (24%)
		TM helix 4	202..223	CDD:320331	5/20 (25%)
		TM helix 5	258..287	CDD:320331	7/31 (23%)
		TM helix 6	310..340	CDD:320331	6/29 (21%)
		TM helix 7	352..377	CDD:320331	8/24 (33%)
OPRM1	NP_001138751.1	7tmA_Mu_opioid_R	164..442	CDD:320218	76/302 (25%)
		TM helix 1	165..191	CDD:320218	7/25 (28%)
		TM helix 2	198..224	CDD:320218	9/26 (35%)
		TM helix 3	235..265	CDD:320218	7/29 (24%)
		TM helix 4	277..299	CDD:320218	5/21 (24%)
		TM helix 5	324..353	CDD:320218	7/28 (25%)
		TM helix 6	368..398	CDD:320218	6/29 (21%)
		TM helix 7	410..435	CDD:320218	8/24 (33%)