Protein Alignment NPFR and OPRL1

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001305782.1
• Gene: OPRL1 / 4987
• HGNCID: 8155
• Length: 399
• Species: Homo sapiens
• Alignment Length: 352
• Identity: 98/352 - (27%)
• Similarity: 177/352 - (50%)
• Gaps: 48/352 - (13%)

  Fly    89 LISMYGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWP 153
            ::.:|..:.|.|.|||.||:..::|...|:||.|::|.|||::|.|: |:|:|....:||..:||
Human    54 IVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWP 117

  Fly   154 YGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYPTR--DSLQFVGAVTILAGIWALALL 216
            :|:.  ||||:..:....:|.||.::||::.|||..|.:|.|  |......|..:...|||||.:
Human   118 FGNA--LCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV 180

  Fly   217 LASPLFVYKELINTDTPALLQQIGLQDTIPYCIEDWPSRNGRFYYSIFSLCV---QYLVPILIVS 278
            :..|:            |::....::|....|:.:.|:... ::..:|::|:   .::||:|::|
Human   181 VGVPV------------AIMGSAQVEDEEIECLVEIPTPQD-YWGPVFAICIFLFSFIVPVLVIS 232

  Fly   279 VAYFGIYNKLKSRITVVAVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADME 343
            |.|..:..:|:      .|:..|..|  |:.|.::|...|::.:..:|...|.|:..|.|...:.
Human   233 VCYSLMIRRLR------GVRLLSGSR--EKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLG 289

  Fly   344 RSPVTQSMLVRYAICHMIGMSSACSNPLLYGWLNDNFRKEFQELLC--------RCSD------T 394
            ..|.:::.:.....|..:|..::|.||:||.:|::||:..|::..|        :.||      .
Human   290 VQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAK 354

  Fly   395 NVALNGHTTGCNVQAAARRRRKLGAEL 421
            :|||     .|.......|.. ||.:|
Human   355 DVAL-----ACKTSETVPRPAXLGVDL 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	86/299 (29%)
		TM helix 1	88..114	CDD:320331	8/24 (33%)
		TM helix 2	121..146	CDD:320331	10/24 (42%)
		TM helix 3	161..191	CDD:320331	11/29 (38%)
		TM helix 4	202..223	CDD:320331	7/20 (35%)
		TM helix 5	258..287	CDD:320331	8/31 (26%)
		TM helix 6	310..340	CDD:320331	8/29 (28%)
		TM helix 7	352..377	CDD:320331	7/24 (29%)
OPRL1	NP_001305782.1	7tmA_NOFQ_opioid_R	52..330	CDD:320220	86/299 (29%)
		TM helix 1	53..79	CDD:320220	8/24 (33%)
		TM helix 2	86..112	CDD:320220	10/26 (38%)
		TM helix 3	123..153	CDD:320220	11/29 (38%)
		TM helix 4	165..187	CDD:320220	7/33 (21%)
		TM helix 5	212..241	CDD:320220	8/28 (29%)
		TM helix 6	256..286	CDD:320220	8/29 (28%)
		TM helix 7	298..323	CDD:320220	7/24 (29%)