Protein Alignment NPFR and OPRD1

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_000902.3
• Gene: OPRD1 / 4985
• HGNCID: 8153
• Length: 372
• Species: Homo sapiens
• Alignment Length: 357
• Identity: 96/357 - (26%)
• Similarity: 176/357 - (49%)
• Gaps: 52/357 - (14%)

  Fly    89 LISMYGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWP 153
            :.::|..:...|.|||.||:..::|...|:||.|::|.|||::| .|...|:|....:.|.:.||
Human    52 ITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSAKYLMETWP 115

  Fly   154 YGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYPTRDSLQF---VGAVTILAGIWALAL 215
            :|  .:|||.:..:....:|.|..::|.::.|||..:.:|.: :|.|   ..|..|...||.||.
Human   116 FG--ELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVK-ALDFRTPAKAKLINICIWVLAS 177

  Fly   216 LLASPLFVYKELINTDTPALLQQIGLQDTIPYCIEDWPSRNGRFYYSIFSLCV---QYLVPILIV 277
            .:..|:.|    :....|        :|....|:..:||.:. ::.::..:||   .::|||||:
Human   178 GVGVPIMV----MAVTRP--------RDGAVVCMLQFPSPSW-YWDTVTKICVFLFAFVVPILII 229

  Fly   278 SVAYFGIYNKLKSRITVVAVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNL---Y 339
            :|.|..:..:|:|      |:..|..:  |:.|.::|...:::.:...|.|.|.|::.|.:   .
Human   230 TVCYGLMLLRLRS------VRLLSGSK--EKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTL 286

  Fly   340 ADME-RSPVTQSMLVRYAICHMIGMSSACSNPLLYGWLNDNFRKEFQELLCR--CSDTNVALNGH 401
            .|:: |.|:..:.|   .:|..:|.:::..||:||.:|::||::.|:: |||  |...:     .
Human   287 VDIDRRDPLVVAAL---HLCIALGYANSSLNPVLYAFLDENFKRCFRQ-LCRKPCGRPD-----P 342

  Fly   402 TTGCNVQAAARRRRKLGAELSKGELKLLGPGG 433
            ::....:.|..|.|......|.      ||||
Human   343 SSFSRAREATARERVTACTPSD------GPGG 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	83/304 (27%)
		TM helix 1	88..114	CDD:320331	7/24 (29%)
		TM helix 2	121..146	CDD:320331	9/24 (38%)
		TM helix 3	161..191	CDD:320331	8/29 (28%)
		TM helix 4	202..223	CDD:320331	7/20 (35%)
		TM helix 5	258..287	CDD:320331	9/31 (29%)
		TM helix 6	310..340	CDD:320331	7/32 (22%)
		TM helix 7	352..377	CDD:320331	7/24 (29%)
OPRD1	NP_000902.3	7tmA_Delta_opioid_R	50..329	CDD:320217	83/304 (27%)
		TM helix 1	51..77	CDD:320217	7/24 (29%)
		TM helix 2	84..110	CDD:320217	9/26 (35%)
		TM helix 3	121..151	CDD:320217	8/29 (28%)
		TM helix 4	163..185	CDD:320217	7/21 (33%)
		TM helix 5	209..239	CDD:320217	9/29 (31%)
		TM helix 6	258..284	CDD:320217	6/25 (24%)
		TM helix 7	297..322	CDD:320217	7/27 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..372		8/40 (20%)