DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NPFR and NPY2R

DIOPT Version :9

Sequence 1:	NP_001246947.1	Gene:	NPFR / 40754	FlyBaseID:	FBgn0037408	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_000901.1	Gene:	NPY2R / 4887	HGNCID:	7957	Length:	381	Species:	Homo sapiens

Alignment Length:	367	Identity:	118/367 - (32%)
Similarity:	188/367 - (51%)	Gaps:	43/367 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 DPVLIDRFLSNRAVDSPWYHMLISMYGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISD 132
            :|.|||   |.:.::.  ..:||..|..:|:.|.:||:||:..||:...|||..|.||.|||::|
Human    37 EPELID---STKLIEV--QVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVAD 96

  Fly   133 LLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYPTRDS 197
            ||:..:.:|.||...|...|..|  .:||..:...|.|.:.||||::|.||.||::.|||.....
Human    97 LLVNTLCLPFTLTYTLMGEWKMG--PVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESK 159

  Fly   198 LQFVGAVTILAGIWALALLLASPLFVYKELINTDTPALLQQIGLQDTIP-----YCIEDWPSRNG 257
            :....:..|:...|.::.||||||.:::|            ..|.:.||     .|.|.||....
Human   160 ISKRISFLIIGLAWGISALLASPLAIFRE------------YSLIEIIPDFEIVACTEKWPGEEK 212

  Fly   258 RFY---YSIFSLCVQYLVPILIVSVAYFGIYNKLKSRITVVAVQASSAQRKVERGRRMKRTNCLL 319
            ..|   ||:.||.:.|::|:.|:|.:|..|::|||:.::..|......||:       ::|..:|
Human   213 SIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRR-------QKTTKML 270

  Fly   320 ISIAIIFGVSWLPLNFFNLYADMERS--PVTQSMLVRYAICHMIGMSSACSNPLLYGWLNDNFRK 382
            :.:.::|.||||||:.|.|..|::..  .:.:..|: :.:.|:|.|.|..:|||||||:|.|:||
Human   271 VCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLI-FTVFHIIAMCSTFANPLLYGWMNSNYRK 334

  Fly   383 EFQELLCRCSDTNVALNGHTTGCNVQAAARRRRKLGAELSKG 424
            .|.... ||.....|::.     .|....:.::.|....:.|
Human   335 AFLSAF-RCEQRLDAIHS-----EVSVTFKAKKNLEVRKNSG 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tm_4	98..>195	CDD:304433	41/96 (43%)
NPFR	NP_001246947.1	7tm_1	103..373	CDD:278431	93/279 (33%)
NPY2R	NP_000901.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		7tmA_NPY2R	51..336	CDD:320521	106/306 (35%)
		TM helix 1	52..78	CDD:320521	11/25 (44%)
		TM helix 2	85..110	CDD:320521	12/24 (50%)
		TM helix 3	123..153	CDD:320521	12/29 (41%)
		TM helix 4	164..185	CDD:320521	8/20 (40%)
		TM helix 5	216..245	CDD:320521	10/28 (36%)
		TM helix 6	261..291	CDD:320521	13/36 (36%)
		TM helix 7	304..329	CDD:320521	12/25 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41034
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010