Protein Alignment NPFR and NMBR

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_002502.2
• Gene: NMBR / 4829
• HGNCID: 7843
• Length: 390
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 102/396 - (25%)
• Similarity: 169/396 - (42%)
• Gaps: 73/396 - (18%)

  Fly    56 TSDLNETGSRP----LDPVLIDRFLSNRAVDSPWYHMLI-----SMYGVLIVFGALGNTLVVIAV 111
            |:..||:||.|    .|      ||.  |.|.....::|     |:|.::|..|.|||.::|...
Human    12 TTGANESGSVPEGWERD------FLP--ASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIF 68

  Fly   112 IRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVST 176
            |....||:..|:||.|||..||||.|..:|:.........|.:|  .:.||.|.::|...:.||.
Human    69 ITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFG--KVGCKLIPVIQLTSVGVSV 131

  Fly   177 ISITAIAFDRYQVIVYPTRDSLQFVGAV----TILAGIWALALLLASPLFVYKELINTDTPALLQ 237
            .::||::.|||:.||.|.  .:|..||:    ....|||.:::|||.|..|:.|:....:   |.
Human   132 FTLTALSADRYRAIVNPM--DMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISS---LD 191

  Fly   238 QIGLQDTIPYCIED--WPSRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKL-KSRITVVAVQA 299
            .......|||...|  .|.     .:|:....|.:|:|:.|:|:.|:.|...| ||...:.....
Human   192 NSSFTACIPYPQTDELHPK-----IHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYN 251

  Fly   300 SSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERSPVTQSM--LVRYAICHMIG 362
            ...::::|..:|:.:...:.:...|.   .|.|.:...:|.....:.:..|:  ::...:..::.
Human   252 EHTKKQMETRKRLAKIVLVFVGCFIF---CWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLS 313

  Fly   363 MSSACSNPLLYGWLNDNFRKEFQELLCRCS-------------------------------DTNV 396
            ..::|.||.....|:::||:.|...|| |.                               ..:|
Human   314 FGNSCVNPFALYLLSESFRRHFNSQLC-CGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSV 377

  Fly   397 ALNGHT 402
            .||||:
Human   378 LLNGHS 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	82/309 (27%)
		TM helix 1	88..114	CDD:320331	10/30 (33%)
		TM helix 2	121..146	CDD:320331	12/24 (50%)
		TM helix 3	161..191	CDD:320331	11/29 (38%)
		TM helix 4	202..223	CDD:320331	9/24 (38%)
		TM helix 5	258..287	CDD:320331	8/28 (29%)
		TM helix 6	310..340	CDD:320331	4/29 (14%)
		TM helix 7	352..377	CDD:320331	3/24 (13%)
NMBR	NP_002502.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		5/9 (56%)
		7tmA_NMBR	44..335	CDD:320253	81/305 (27%)
		TM helix 1	45..71	CDD:320253	9/25 (36%)
		TM helix 2	78..104	CDD:320253	12/25 (48%)
		TM helix 3	116..146	CDD:320253	11/29 (38%)
		TM helix 4	158..178	CDD:320253	6/19 (32%)
		TM helix 5	209..234	CDD:320253	8/29 (28%)
		TM helix 6	259..289	CDD:320253	5/32 (16%)
		TM helix 7	303..328	CDD:320253	3/24 (13%)