DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NPFR and npy7r

DIOPT Version :9

Sequence 1:	NP_001246947.1	Gene:	NPFR / 40754	FlyBaseID:	FBgn0037408	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001007219.1	Gene:	npy7r / 449010	ZFINID:	ZDB-GENE-040924-9	Length:	372	Species:	Danio rerio

Alignment Length:	382	Identity:	117/382 - (30%)
Similarity:	188/382 - (49%)	Gaps:	52/382 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ALNTTAINTSDLNETGSRPLDPVLIDRFLSNRAVDSPWYHMLISMYGVLIVFGALGNTLVVIAVI 112
            :|...::||          ..|..:|....:.:|..    .||..|.::|:.|.:|||||:..:|
Zfish    23 SLGNDSVNT----------YKPAFVDDITKHLSVQI----SLILAYSLIILLGLVGNTLVIYMII 73

  Fly   113 RKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTI 177
            ....|||..|.||.|||::||::..|.:|.||:..|...|.:|  :::|..:...|||.:.||.:
Zfish    74 LYRNMRTVTNYFIANLALADLMVDTVCLPFTLVYTLLDEWKFG--AVMCHMVPYSQALSVHVSIL 136

  Fly   178 SITAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALALLLASPLFVYKELINTDTPALLQQIGLQ 242
            ::|.||.:||:.||:.....|....:..|:...||.|.:||.||.:::|....:.|.:..:|.:
Zfish   137 TLTIIALERYRCIVFHLGQRLNRCTSFIIIGLTWAFAAILAGPLAIFREYRYEEIPYIDLRIAV- 200

  Fly   243 DTIPYCIEDWPSRNGR--FYYSIFSLCVQYLVPILIVSVAYFGIYNKLKSRITVVAVQASSAQRK 305
                 |.|.||:...|  ..||:..|.:||:||:.|:|.||..|:.|||:.:        |...:
Zfish   201 -----CSEKWPNGTNRDAVIYSLSMLLLQYVVPLAIISYAYVCIWIKLKNHV--------SPSNR 252

  Fly   306 VERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERSPVTQSMLVRYAICHMIGMSSACSNP 370
            .:...|.|:|..:|..:.::|.|.|||.:.|.|.:|::.....:...:.|.:.|::.|.|...||
Zfish   253 NDGIVRRKKTTKMLALVVVVFAVCWLPFHMFQLASDLDLILKFKEYKLIYTLFHIVAMCSTFVNP 317

  Fly   371 LLYGWLNDNFRKEFQELLCRC----------------SDTNVALNGHTTGCNVQAAA 411
            |||||:|.|:|..|. :..||                |...:.:||:..|   |.||
Zfish   318 LLYGWMNQNYRNGFL-MFFRCEHKPDSIYPDGSFRTRSLRGMIVNGYNDG---QPAA 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tm_4	98..>195	CDD:304433	38/96 (40%)
NPFR	NP_001246947.1	7tm_1	103..373	CDD:278431	89/271 (33%)
npy7r	NP_001007219.1	7tm_GPCRs	48..331	CDD:333717	101/302 (33%)
		TM helix 1	50..74	CDD:320095	10/23 (43%)
		TM helix 2	83..105	CDD:320095	10/21 (48%)
		TM helix 3	121..143	CDD:320095	7/21 (33%)
		TM helix 4	164..180	CDD:320095	6/15 (40%)
		TM helix 5	214..237	CDD:320095	10/22 (45%)
		TM helix 6	260..285	CDD:320095	9/24 (38%)
		TM helix 7	299..324	CDD:320095	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I3972
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24235
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3897
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.040