Protein Alignment NPFR and HCRTR1

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001516.2
• Gene: HCRTR1 / 3061
• HGNCID: 4848
• Length: 425
• Species: Homo sapiens
• Alignment Length: 470
• Identity: 117/470 - (24%)
• Similarity: 205/470 - (43%)
• Gaps: 108/470 - (22%)

  Fly    63 GSR---PLDPVLIDRFL----SNRAVDSPWYHMLISMYGVLIVFGALGNTLVVIAVIRKPIMRTA 120
            |||   |:.|...|.||    .:......:..:||:.|..:.|...:|||||.:||.|...|||.
Human    16 GSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTV 80

  Fly   121 RNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTISITAIAFD 185
            .|.||:||:::|:|:..:.:|.:|:..:::.|.:|..  |||.|..|||:.:.|:.::::.||.|
Human    81 TNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHA--LCKVIPYLQAVSVSVAVLTLSFIALD 143

  Fly   186 RYQVIVYPTRDSLQFVGAVTILAGIWALALLLASPLFVYKELINTDTPALLQQIGLQDTIPYCIE 250
            |:..|.:|.........|...:.||||::|.:..|.....| .::..|.|..:..|   ...|.|
Human   144 RWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVME-CSSVLPELANRTRL---FSVCDE 204

  Fly   251 DW-----PSRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKLKSR----ITVVAV--------- 297
            .|     |    :.|:|.|.: |.||.|:.::::|||.|:.||..|    .|...|
Human   205 RWADDLYP----KIYHSCFFI-VTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQ 264

  Fly   298 --------------QASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFN----LYADMER 344
                          :|.:...:|::.|..::|..:|:.:.::|.:.:||::..|    ::....:
Human   265 LGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQ 329

  Fly   345 SPVTQSMLVRYAICHMIGMSSACSNPLLYGWLNDNFRKEFQELLCRCSDTNVALNGHTTGCNVQA 409
            :...:::...:...|.:..:::.:||::|.:|:..||::|:.....|      |.|
Human   330 ASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCC------LPG--------- 379

  Fly   410 AARRRRKLGAELSKGELKLLGPGGAQSGTAGGEGGLAATDFMTGHHEGGLR-----SAITESVAL 469
                   ||   ..|.||...|..:.|                 |....|:     |.|:|.|.|
Human   380 -------LG---PCGSLKAPSPRSSAS-----------------HKSLSLQSRCSISKISEHVVL 417

  Fly   470 TDHNPVPSEVTKLMP 484
            |       .||.::|
Human   418 T-------SVTTVLP 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	87/331 (26%)
		TM helix 1	88..114	CDD:320331	11/25 (44%)
		TM helix 2	121..146	CDD:320331	9/24 (38%)
		TM helix 3	161..191	CDD:320331	11/29 (38%)
		TM helix 4	202..223	CDD:320331	7/20 (35%)
		TM helix 5	258..287	CDD:320331	11/28 (39%)
		TM helix 6	310..340	CDD:320331	7/33 (21%)
		TM helix 7	352..377	CDD:320331	4/24 (17%)
HCRTR1	NP_001516.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		4/7 (57%)
		Required for response to orexin-A. /evidence=ECO:0000269|PubMed:26950369	26..41		3/14 (21%)
		7tmA_OXR	47..369	CDD:320336	87/332 (26%)
		TM helix 1	48..74	CDD:320336	11/25 (44%)
		TM helix 2	81..107	CDD:320336	9/25 (36%)
		TM helix 3	119..149	CDD:320336	11/29 (38%)
		TM helix 4	160..181	CDD:320336	7/20 (35%)
		TM helix 5	212..241	CDD:320336	12/33 (36%)
		TM helix 6	291..321	CDD:320336	7/29 (24%)
		TM helix 7	337..362	CDD:320336	4/24 (17%)