DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NPFR and Npy1r

DIOPT Version :9

Sequence 1:	NP_001246947.1	Gene:	NPFR / 40754	FlyBaseID:	FBgn0037408	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001106828.1	Gene:	Npy1r / 29358	RGDID:	3198	Length:	382	Species:	Rattus norvegicus

Alignment Length:	355	Identity:	108/355 - (30%)
Similarity:	173/355 - (48%)	Gaps:	48/355 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 YGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSC 157
            ||.:|:.|..||..::|.::::..||...|:.|:||:.||||:.::.:|.|.:..|..:|.:|
  Rat    46 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVYTLMDHWVFG-- 108

  Fly   158 SILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYP----TRDSLQFVGAVTILAGIWALALLLA 218
            ..:||....:|.:.|.||..|:..||.:|:|:|:.|    ..:...::| :|:   ||.||:..:
  Rat   109 ETMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYIG-ITV---IWVLAVASS 169

  Fly   219 SPLFVYKELINTDTPALLQQIGL---QDTIPYCIEDWPSRNGRFYYSIFSLCVQYLVPILIVSVA 280
            .|..:|:  |.||.|  .|.:.|   :|.. .|.:.:||.:.|..|:...|.:||..|:..:.:.
  Rat   170 LPFVIYQ--ILTDEP--FQNVSLAAFKDKY-VCFDKFPSDSHRLSYTTLLLVLQYFGPLCFIFIC 229

  Fly   281 YFGIYNKLKSRITVVAVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERS 345
            ||.||.:||.|..::.....|..|..|    .||.|.:|:||.:.|.|.||||..||...|....
  Rat   230 YFKIYVRLKRRNNMMDKIRDSKYRSSE----TKRINVMLLSIVVAFAVCWLPLTIFNTVFDWNHQ 290

  Fly   346 PV-TQSMLVRYAICHMIGMSSACSNPLLYGWLNDNFRKEFQELLCRCS--------DTNVALNGH 401
            .: |.:..:.:.:||:..|.|.|.||:.||:||.||:::.|.....|.        :|......|
  Rat   291 IIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMH 355

  Fly   402 TTGCNVQAAARRRRKLGAELSKGELKLLGP 431
            |                 ::||..||...|
  Rat   356 T-----------------DVSKTSLKQASP 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tm_4	98..>195	CDD:304433	32/100 (32%)
NPFR	NP_001246947.1	7tm_1	103..373	CDD:278431	88/277 (32%)
Npy1r	NP_001106828.1	7tmA_NPY1R	40..330	CDD:320517	98/298 (33%)
		TM helix 1	42..66	CDD:320517	7/19 (37%)
		TM helix 2	75..97	CDD:320517	9/21 (43%)
		TM helix 3	113..135	CDD:320517	7/21 (33%)
		TM helix 4	156..172	CDD:320517	6/19 (32%)
		TM helix 5	208..231	CDD:320517	5/22 (23%)
		TM helix 6	261..283	CDD:320517	11/21 (52%)
		TM helix 7	298..323	CDD:320517	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I3993
eggNOG	1	0.900	-	-		E33208_3BAX7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	178	1.000	Inparanoid score	I3922
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.970