Protein Alignment NPFR and Oprl1

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001305876.1
• Gene: Oprl1 / 29256
• RGDID: 68438
• Length: 396
• Species: Rattus norvegicus
• Alignment Length: 391
• Identity: 106/391 - (27%)
• Similarity: 189/391 - (48%)
• Gaps: 62/391 - (15%)

  Fly    55 NTSDLNETGSRPLDPVLIDRFLSNRAVDSPWYHM-----LISMYGVLIVFGALGNTLVVIAVIRK 114
            |.|.||||         :...|...|..|.:..:     ::.:|..:.:.|.|||.||:..::|.
  Rat    21 NLSLLNET---------VPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRH 76

  Fly   115 PIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTISI 179
            ..|:||.|::|.|||::|.|: |:|:|....:||..:||:|:.  ||||:..:....:|.||.::
  Rat    77 TKMKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNA--LCKTVIAIDYYNMFTSTFTL 138

  Fly   180 TAIAFDRYQVIVYPTR--DSLQFVGAVTILAGIWALALLLASPLFVYKELINTDTPALLQQIGLQ 242
            ||::.|||..|.:|.|  |......|..:...|||||.::..|:            |::....::
  Rat   139 TAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPV------------AIMGSAQVE 191

  Fly   243 DTIPYCIEDWPSRNGRFYYSIFSLCV---QYLVPILIVSVAYFGIYNKLKSRITVVAVQASSAQR 304
            |....|:.:.|:... ::..:|::|:   .:::|:||:||.|..:..:|:      .|:..|..|
  Rat   192 DEEIECLVEIPAPQD-YWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLR------GVRLLSGSR 249

  Fly   305 KVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERSPVTQSMLVRYAICHMIGMSSACSN 369
              |:.|.::|...|::.:..:|...|.|:..|.|...:...|.:::.:.....|..:|..::|.|
  Rat   250 --EKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLN 312

  Fly   370 PLLYGWLNDNFRKEFQELLC--------RCSD------TNVALNGHTTGCNVQAAARRRRKLGAE 420
            |:||.:|::||:..|::..|        :.||      .:|.|     ||.......|...||.:
  Rat   313 PILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGL-----GCKTSETVPRPAXLGVD 372

  Fly   421 L 421
            |
  Rat   373 L 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	85/305 (28%)
		TM helix 1	88..114	CDD:320331	7/30 (23%)
		TM helix 2	121..146	CDD:320331	10/24 (42%)
		TM helix 3	161..191	CDD:320331	11/29 (38%)
		TM helix 4	202..223	CDD:320331	7/20 (35%)
		TM helix 5	258..287	CDD:320331	8/31 (26%)
		TM helix 6	310..340	CDD:320331	8/29 (28%)
		TM helix 7	352..377	CDD:320331	7/24 (29%)
Oprl1	NP_001305876.1	7tmA_NOFQ_opioid_R	49..327	CDD:320220	85/301 (28%)
		TM helix 1	50..76	CDD:320220	7/25 (28%)
		TM helix 2	83..109	CDD:320220	10/26 (38%)
		TM helix 3	120..150	CDD:320220	11/29 (38%)
		TM helix 4	162..184	CDD:320220	7/33 (21%)
		TM helix 5	209..238	CDD:320220	8/28 (29%)
		TM helix 6	253..283	CDD:320220	8/29 (28%)
		TM helix 7	295..320	CDD:320220	7/24 (29%)