DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NPFR and PRLHR

DIOPT Version :9

Sequence 1:	NP_001246947.1	Gene:	NPFR / 40754	FlyBaseID:	FBgn0037408	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_004239.2	Gene:	PRLHR / 2834	HGNCID:	4464	Length:	370	Species:	Homo sapiens

Alignment Length:	313	Identity:	112/313 - (35%)
Similarity:	173/313 - (55%)	Gaps:	36/313 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 MLISMYGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILS-KY 151
            :::.:|.|::|.|.:||.|:|:.:.|...:....|..|.|||:||:|:|...:||||..... :.
Human    62 LIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRG 126

  Fly   152 WPYGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYPTRDSLQF-VGAVTILAGIWALAL 215
            |.:|..  ||..:..||.:.::||..::|.||.|||.|:|:|.|..:.. :.|..:|| ||||:.
Human   127 WVFGGG--LCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLA-IWALSA 188

  Fly   216 LLASPLFVYK---ELINTDTPALLQQIGLQDTIPYCIEDWPSR-NGRFYYSIFSLCVQYLVPILI 276
            :||.|..|:.   ||...|             :..|.|.|.|: ..|..|:...|.|.||:|:|:
Human   189 VLALPAAVHTYHVELKPHD-------------VRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLV 240

  Fly   277 VSVAYFGIYNKLKSRITVVAVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYAD 341
            :.::|..:..||::|:....|..|.|.  .:|.|| :||.|||:.|.::|.|.||||:.|||..|
Human   241 ILLSYVRVSVKLRNRVVPGCVTQSQAD--WDRARR-RRTFCLLVVIVVVFAVCWLPLHVFNLLRD 302

  Fly   342 MERSPVTQSMLVRYA------ICHMIGMSSACSNPLLYGWLNDNFRKEFQELL 388
            ::...:..     ||      :||.:.|||||.||.:|.||:|:||:|.::||
Human   303 LDPHAIDP-----YAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLL 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tm_4	98..>195	CDD:304433	37/97 (38%)
NPFR	NP_001246947.1	7tm_1	103..373	CDD:278431	99/281 (35%)
PRLHR	NP_004239.2	7tmA_PrRP_R	77..346	CDD:320516	105/292 (36%)
		TM helix 2	95..120	CDD:320516	13/24 (54%)
		TM helix 3	134..164	CDD:320516	12/29 (41%)
		TM helix 4	175..196	CDD:320516	10/21 (48%)
		TM helix 5	222..251	CDD:320516	9/28 (32%)
		TM helix 6	271..301	CDD:320516	17/30 (57%)
		TM helix 7	314..339	CDD:320516	11/24 (46%)
		Required for interaction with GRIP1, GRIP2 and PICK1. /evidence=ECO:0000269\|PubMed:11641419	365..370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010