Protein Alignment NPFR and Brs3

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_690058.1
• Gene: Brs3 / 260319
• RGDID: 628645
• Length: 399
• Species: Rattus norvegicus
• Alignment Length: 429
• Identity: 106/429 - (24%)
• Similarity: 184/429 - (42%)
• Gaps: 84/429 - (19%)

  Fly    50 NTTAINTSDLNETGSRPLDPVLIDRFLSNRAV-------DSPWYHMLISM---YGVLIVFGALGN 104
            |.|.|:.::..||.|..         :||...       :||....|.::   |.|:|..|.|||
  Rat    10 NQTLISITNDTETSSSA---------VSNDTTPKGWTGDNSPGIEALCAIYITYAVIISVGILGN 65

  Fly   105 TLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQA 169
            .:::....:...|:|..|:||.:||..||||.|..:|:.....|::.|.:|  .:.||.::.::.
  Rat    66 AILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFG--KVGCKVLSFIRL 128

  Fly   170 LCIFVSTISITAIAFDRYQVIVYP--TRDSLQFVGAVTILAGIWALALLLASPLFVYKELINTDT 232
            ..:.||..::|.::.|||:.:|.|  .:.|...:.......|||.:|::.|.|..::..:
  Rat   129 TSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCAKAGGIWIMAMIFALPEAIFSNV----- 188

  Fly   233 PALLQQIGLQDTIPYCIEDWPSRNGRF---------------YYSIFSLCVQYLVPILIVSVAYF 282
                          |..:| |:||..|               .:|:....|.|::|:.|:||.|.
  Rat   189 --------------YTFQD-PNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYS 238

  Fly   283 GIYNKL-KSRITVVAVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERSP 346
            .|...| ||.:.:...:.|.|::::|..:|:.:|..:|::   :|.:.|||.:...||.......
  Rat   239 LIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVA---LFALCWLPNHLLYLYHSFTYES 300

  Fly   347 VTQSMLVRYAI---CHMIGMSSACSNPLLYGWLNDNFRKEFQELLCRC----------SDTNVAL 398
            ..:...|.:.:   ..::..|::|.||....||:..|:|.|:..|| |          .||  .|
  Rat   301 YAEPSDVPFVVTIFSRVLAFSNSCVNPFALYWLSKTFQKHFKAQLC-CFKAEQPEPPLGDT--PL 362

  Fly   399 NGHTTGCNVQAAARRRRKLGAELSKGELKLLGPGGAQSG 437
            |..|....|.|..      .|.:|:..:.|.....|:.|
  Rat   363 NNLTVMGRVPATG------SAHVSEISVTLFSGSTAKKG 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	80/319 (25%)
		TM helix 1	88..114	CDD:320331	8/28 (29%)
		TM helix 2	121..146	CDD:320331	11/24 (46%)
		TM helix 3	161..191	CDD:320331	8/29 (28%)
		TM helix 4	202..223	CDD:320331	6/20 (30%)
		TM helix 5	258..287	CDD:320331	10/43 (23%)
		TM helix 6	310..340	CDD:320331	8/29 (28%)
		TM helix 7	352..377	CDD:320331	6/27 (22%)
Brs3	NP_690058.1	7tm_GPCRs	48..341	CDD:475119	79/317 (25%)
		TM helix 1	50..74	CDD:320251	7/23 (30%)
		TM helix 2	83..105	CDD:320251	11/21 (52%)
		TM helix 3	121..143	CDD:320251	4/21 (19%)
		TM helix 4	166..182	CDD:320251	5/15 (33%)
		TM helix 5	215..238	CDD:320251	7/22 (32%)
		TM helix 6	270..292	CDD:320251	6/24 (25%)
		TM helix 7	309..334	CDD:320251	5/24 (21%)