Protein Alignment NPFR and Nmbr

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_036931.1
• Gene: Nmbr / 25264
• RGDID: 3181
• Length: 390
• Species: Rattus norvegicus
• Alignment Length: 401
• Identity: 108/401 - (26%)
• Similarity: 173/401 - (43%)
• Gaps: 76/401 - (18%)

  Fly    55 NTSDLNETGSRPLDP-VLIDRFLSNRAVDSPWYHMLI-----SMYGVLIVFGALGNTLVVIAVIR 113
            |.|...|.....|:| |..:.||.:.  |.....::|     |:|.::|..|.|||.::|...:.
  Rat     8 NLSLPTEASESELEPEVWENDFLPDS--DGTTAELVIRCVIPSLYLIIISVGLLGNIMLVKIFLT 70

  Fly   114 KPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTIS 178
            ...||:..|:||.|||..||||.|..:|:.........|.:|...  ||.|..:|...:.||..:
  Rat    71 NSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLG--CKLIPAIQLTSVGVSVFT 133

  Fly   179 ITAIAFDRYQVIVYPTRDSLQFVGAV--TIL--AGIWALALLLASPLFVYKELINTDTPALLQQI 239
            :||::.|||:.||.|.  .:|..|.|  |.|  .|||.:::|||.|..|:.|         :.:|
  Rat   134 LTALSADRYRAIVNPM--DMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSE---------VARI 187

  Fly   240 GLQDT------IPYCIED--WPSRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKL-KSRITVV 295
            |..|.      |||...|  .|.     .:|:....|.:|:|::|:|:.|:.|...| :|...:.
  Rat   188 GSSDNSSFTACIPYPQTDELHPK-----IHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLP 247

  Fly   296 AVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERSPVTQSM--LVRYAIC 358
            .......::::|..:|:.:   :::.....|...|.|.:...||.......:..|:  ::...:.
  Rat   248 GEYNEHTKKQMETRKRLAK---IVLVFVGCFVFCWFPNHILYLYRSFNYKEIDPSLGHMIVTLVA 309

  Fly   359 HMIGMSSACSNPLLYGWLNDNFRKEFQELLCRCSD------------------------------ 393
            .::..|::|.||.....|:::|||.|...|| |..
  Rat   310 RVLSFSNSCVNPFALYLLSESFRKHFNSQLC-CGQKSYPERSTSYLLSSSAVRMTSLKSNAKNVV 373

  Fly   394 TN-VALNGHTT 403
            || |.||||:|
  Rat   374 TNSVLLNGHST 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	87/315 (28%)
		TM helix 1	88..114	CDD:320331	9/30 (30%)
		TM helix 2	121..146	CDD:320331	12/24 (50%)
		TM helix 3	161..191	CDD:320331	11/29 (38%)
		TM helix 4	202..223	CDD:320331	11/24 (46%)
		TM helix 5	258..287	CDD:320331	8/28 (29%)
		TM helix 6	310..340	CDD:320331	5/29 (17%)
		TM helix 7	352..377	CDD:320331	4/24 (17%)
Nmbr	NP_036931.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		3/11 (27%)
		7tm_GPCRs	44..335	CDD:475119	86/311 (28%)
		TM helix 1	46..70	CDD:410628	8/23 (35%)
		TM helix 2	79..101	CDD:410628	12/21 (57%)
		TM helix 3	117..139	CDD:410628	7/21 (33%)
		TM helix 4	162..178	CDD:410628	7/15 (47%)
		TM helix 5	210..233	CDD:410628	6/27 (22%)
		TM helix 6	265..287	CDD:410628	3/24 (13%)
		TM helix 7	303..328	CDD:410628	4/24 (17%)