Protein Alignment NPFR and Hcrtr1

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_945197.2
• Gene: Hcrtr1 / 230777
• MGIID: 2385650
• Length: 416
• Species: Mus musculus
• Alignment Length: 339
• Identity: 87/339 - (25%)
• Similarity: 168/339 - (49%)
• Gaps: 41/339 - (12%)

  Fly    85 WYHMLISMYGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILS 149
            |  :||:.|..:.:...:|||||.:||.|...|||..|.||:||:::|:|:..:.:|.:|:..::
Mouse    47 W--VLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDIT 109

  Fly   150 KYWPYGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALA 214
            :.|.:|..  |||.|..|||:.:.|:.::::.||.||:..|.:|.........|...:.||||::
Mouse   110 ESWLFGQA--LCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVS 172

  Fly   215 LLLASPLFVYKELINTDTPALLQQIGLQDTIPYCIEDWPSR-NGRFYYSIFSLCVQYLVPILIVS 278
            |.:..|.....| .::..|.|..:..|   ...|.|.|... ..:.|:|.|.: |.||.|:.:::
Mouse   173 LAVMVPQAAVME-CSSVLPELANRTRL---FSVCDEHWADELYPKIYHSCFFI-VTYLAPLGLMA 232

  Fly   279 VAYFGIYNKLKSR---------------------------ITVVAVQASSAQRKVERGRRMKRTN 316
            :|||.|:.||..|                           .|....:|.:...:|::.|..::|.
Mouse   233 MAYFQIFRKLWGRQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTA 297

  Fly   317 CLLISIAIIFGVSWLPLNFFN----LYADMERSPVTQSMLVRYAICHMIGMSSACSNPLLYGWLN 377
            .:|:.:.::|.:.:||::..|    ::....::...:::...:...|.:..:::.:||::|.:|:
Mouse   298 KMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLS 362

  Fly   378 DNFRKEFQELLCRC 391
            ..||::|:.....|
Mouse   363 GKFREQFKAAFSCC 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	84/327 (26%)
		TM helix 1	88..114	CDD:320331	10/25 (40%)
		TM helix 2	121..146	CDD:320331	9/24 (38%)
		TM helix 3	161..191	CDD:320331	11/29 (38%)
		TM helix 4	202..223	CDD:320331	7/20 (35%)
		TM helix 5	258..287	CDD:320331	11/28 (39%)
		TM helix 6	310..340	CDD:320331	7/33 (21%)
		TM helix 7	352..377	CDD:320331	4/24 (17%)
Hcrtr1	NP_945197.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22
		Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43613	26..41
		7tmA_OXR	47..369	CDD:320336	85/330 (26%)
		TM helix 1	48..74	CDD:320336	10/25 (40%)
		TM helix 2	81..107	CDD:320336	9/25 (36%)
		TM helix 3	119..149	CDD:320336	11/29 (38%)
		TM helix 4	160..181	CDD:320336	7/20 (35%)
		TM helix 5	212..241	CDD:320336	11/29 (38%)
		TM helix 6	291..321	CDD:320336	7/29 (24%)
		TM helix 7	337..362	CDD:320336	4/24 (17%)