Protein Alignment NPFR and Prlhr

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_963909.2
• Gene: Prlhr / 226278
• MGIID: 2135956
• Length: 370
• Species: Mus musculus
• Alignment Length: 365
• Identity: 117/365 - (32%)
• Similarity: 189/365 - (51%)
• Gaps: 45/365 - (12%)

  Fly    41 LDLGTVHALNTTAINTSDLNETGSRPLDP--VLIDRFLSNRAVDSPWYH----MLISMYGVLIVF 99
            |..|.:.|.:|.|..:::.:|.......|  ..:..|.|.:.|     |    :::.:|.:::|.
Mouse    14 LSSGLLPASSTPANQSAEASEGNLSATVPRAAAVTPFQSLQLV-----HQLKGLIVMLYSIVVVV 73

  Fly   100 GALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILS-KYWPYGSCSILCKT 163
            |.:||.|:|:.:.|...:....|..|.|||:||:|:|...:||||..... :.|.:|..  ||..
Mouse    74 GLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCAACVPLTLAYAFEPRGWVFGGG--LCHL 136

  Fly   164 IAMLQALCIFVSTISITAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALALLLASPLFVYK--- 225
            :..||.:.::||..::|.||.|||.|:|:|.|..:....:...:.|||||:.:||.|..|:.
Mouse   137 VFFLQPVTVYVSVFTLTTIALDRYVVLVHPLRRRISLRLSAYAVLGIWALSAVLALPAAVHTYHV 201

  Fly   226 ELINTDTPALLQQIGLQDTIPYCIEDWPSR-NGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKLK 289
            ||...|             :..|.|.|.|: ..|..|:...|...||:|:|.:.::|..:..||:
Mouse   202 ELKPHD-------------VSLCEEFWGSQERQRQIYAWGLLLGTYLLPLLAILLSYVRVSVKLR 253

  Fly   290 SRITVVAVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERSPVTQSMLVR 354
            :|  ||....:.:|...:|.|| :||.|||:.:.::|.|.||||:.|||..|::...:..
Mouse   254 NR--VVPGSVTQSQADWDRARR-RRTFCLLVVVVVVFAVCWLPLHIFNLLRDLDPRAIDP----- 310

  Fly   355 YA------ICHMIGMSSACSNPLLYGWLNDNFRKEFQELL 388
            ||      :||.:.|||||.||.:|.||:|:||:|.:::|
Mouse   311 YAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKML 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	104/306 (34%)
		TM helix 1	88..114	CDD:320331	7/25 (28%)
		TM helix 2	121..146	CDD:320331	13/24 (54%)
		TM helix 3	161..191	CDD:320331	12/29 (41%)
		TM helix 4	202..223	CDD:320331	8/20 (40%)
		TM helix 5	258..287	CDD:320331	8/28 (29%)
		TM helix 6	310..340	CDD:320331	16/29 (55%)
		TM helix 7	352..377	CDD:320331	13/30 (43%)
Prlhr	NP_963909.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		5/18 (28%)
		7tmA_PrRP_R	61..346	CDD:320516	104/307 (34%)
		TM helix 1	62..88	CDD:320516	7/25 (28%)
		TM helix 2	95..120	CDD:320516	13/24 (54%)
		TM helix 3	134..164	CDD:320516	12/29 (41%)
		TM helix 4	175..196	CDD:320516	8/20 (40%)
		TM helix 5	222..251	CDD:320516	8/28 (29%)
		TM helix 6	271..301	CDD:320516	16/30 (53%)
		TM helix 7	314..339	CDD:320516	11/24 (46%)
		Required for interaction with GRIP1, GRIP2 and PICK1. /evidence=ECO:0000250	365..370