DRSC/TRiP Functional Genomics Resources

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Protein Alignment NPFR and npr-22

DIOPT Version :9

Sequence 1:NP_001246947.1 Gene:NPFR / 40754 FlyBaseID:FBgn0037408 Length:489 Species:Drosophila melanogaster
Sequence 2:NP_001023541.1 Gene:npr-22 / 190424 WormBaseID:WBGene00022004 Length:434 Species:Caenorhabditis elegans


Alignment Length:324 Identity:92/324 - (28%)
Similarity:159/324 - (49%) Gaps:44/324 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 YHMLISM-------YGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLT 143
            ||:..||       |.:|.|....||.||::.::....:|||.|:.|||||::|||:.:..:|.:
 Worm    43 YHLTPSMKMLCILFYSILCVCCVYGNVLVILVIVYFKRLRTATNILILNLAVADLLISVFCIPFS 107

  Fly   144 LMEIL---SKYWPYGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYPTRDSLQFV--GA 203
            ..::|   .:.|.:|  |::|..:|.|||:.:|:|..::..|:|||:..|::....:::..  .|
 Worm   108 YWQVLIYDDQRWLFG--SMMCSLLAFLQAMAVFLSAWTLVVISFDRWMAIMFLLTPNIRITRRRA 170

  Fly   204 VTILAGIWALALLLASPLFVYKELINTDTPALLQQIGLQDTIPYCIEDW-----PSRNGRFYYSI 263
            :.::|..|..::|:|.||.........           ||.:|.|.|:|     .....|..||.
 Worm   171 LYLVAATWIFSILMALPLLFTTRFFED-----------QDGLPNCGENWTYFGDSGEQVRKVYSS 224

  Fly   264 FSLCVQYLVP--ILIVSVAYFGIYNKLKSRITVVAVQASSAQRK-VERGRRMKRTNCLLISIAII 325
            ..|.:||:||  :||::..:.|| ....||  |..:|..:.::. |:|...:|:...::|.|:.:
 Worm   225 MVLILQYVVPQAVLIITYTHIGI-KMWNSR--VPGMQNGATKKMIVDRHESVKKLVPMVILISAL 286

  Fly   326 FGVSWLPLNFF-----NLYADMERSPVTQSMLVRYAICHMIGMSSACSNPLLYGWLNDNFRKEF 384
            |.:.||||...     ..|.|:..   ...:|..:...|.:.||.:..||::|...|..||:.|
 Worm   287 FALCWLPLLILINVIPEFYPDINS---WGYILYLWWFAHGLAMSHSMVNPIIYFIRNARFREGF 347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NPFRNP_001246947.1 7tm_4 98..>195 CDD:304433 34/99 (34%)
7tm_1 103..373 CDD:278431 80/287 (28%)
npr-22NP_001023541.1 7tmA_PR4-like 51..347 CDD:320514 87/314 (28%)
TM helix 1 52..78 CDD:320514 7/25 (28%)
TM helix 2 85..110 CDD:320514 10/24 (42%)
TM helix 3 126..156 CDD:320514 11/29 (38%)
TM helix 4 169..190 CDD:320514 7/20 (35%)
TM helix 5 219..248 CDD:320514 12/29 (41%)
TM helix 6 271..301 CDD:320514 8/29 (28%)
TM helix 7 315..340 CDD:320514 7/24 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3897
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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