Protein Alignment NPFR and npr-5

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001024265.1
• Gene: npr-5 / 190386
• WormBaseID: WBGene00021983
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 352
• Identity: 100/352 - (28%)
• Similarity: 174/352 - (49%)
• Gaps: 38/352 - (10%)

  Fly    45 TVHALNTTAINTSDLNETGSRPLDPVLIDRFLSNRAVDSPWYHMLISMYGVLIVFGALGNTLVVI 109
            |.|:.|.:.|..::  ...::.:|.:.:|.::.:         :...:||.|.|.|..||..|:.
 Worm    25 TSHSNNGSCIQIAE--AIAAQGIDDITVDFYIRS---------IFTFLYGFLFVLGIFGNGGVLW 78

  Fly   110 AVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFV 174
            ||.|...:::|||:|:|||..:||:|....:|:|....::|.|.:|  |::|..:.:..:..:||
 Worm    79 AVARNKRLQSARNVFLLNLIFTDLILVFTAIPVTPWYAMTKDWAFG--SVMCHLVPLSNSCSVFV 141

  Fly   175 STISITAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALALLLASPLFVYKELINTDTPALLQQI 239
            ::.|:|||:.|::..|..||:..:....|:.|...||.::.|:..|..:..|  :.|....:|
 Worm   142 TSWSLTAISLDKFLHINDPTKQPVSIRQALAITFLIWIVSTLINLPYLMSFE--HVDGSFYVQ-- 202

  Fly   240 GLQDTIPYC-----IEDWPSRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKLKSRITVVAVQA 299
              ....|||     ..:|.|.|.|..|....:.:|::||:.:::..||.|..|:...:.:...|.
 Worm   203 --PGETPYCGHFCDEANWQSENSRKIYGTTVMLLQFVVPMAVITYCYFKILQKVSKDMIIQNAQF 265

  Fly   300 SSAQRKVERG---RRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERSPVTQSMLVR----YAI 357
            ..:..:.:|.   .|.|:.|.:||::.:.|...||||...||..|.::.|   ..|.|    :||
 Worm   266 CQSLTQKQRSDATSRKKKVNYILIAMVVTFIGCWLPLTLLNLVKDFKKEP---EWLKRQPFFWAI 327

  Fly   358 -CHMIGMSSACSNPLLYGWLNDNFRKE 383
             .|:|.||....||||:.||.   ||:
 Worm   328 NAHVIAMSLVVWNPLLFFWLT---RKQ 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	94/309 (30%)
		TM helix 1	88..114	CDD:320331	10/25 (40%)
		TM helix 2	121..146	CDD:320331	11/24 (46%)
		TM helix 3	161..191	CDD:320331	8/29 (28%)
		TM helix 4	202..223	CDD:320331	6/20 (30%)
		TM helix 5	258..287	CDD:320331	8/28 (29%)
		TM helix 6	310..340	CDD:320331	12/29 (41%)
		TM helix 7	352..377	CDD:320331	13/29 (45%)
npr-5	NP_001024265.1	7tmA_NPYR-like	56..347	CDD:320331	90/310 (29%)
		TM helix 1	57..83	CDD:320331	10/25 (40%)
		TM helix 2	90..115	CDD:320331	11/24 (46%)
		TM helix 3	128..158	CDD:320331	8/29 (28%)
		TM helix 4	169..190	CDD:320331	6/20 (30%)
		TM helix 5	224..253	CDD:320331	8/28 (29%)
		TM helix 6	279..309	CDD:320331	12/29 (41%)
		TM helix 7	323..347	CDD:320331	10/23 (43%)