DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NPFR and npr-7

DIOPT Version :9

Sequence 1:	NP_001246947.1	Gene:	NPFR / 40754	FlyBaseID:	FBgn0037408	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_509570.3	Gene:	npr-7 / 185321	WormBaseID:	WBGene00018067	Length:	380	Species:	Caenorhabditis elegans

Alignment Length:	340	Identity:	86/340 - (25%)
Similarity:	168/340 - (49%)	Gaps:	50/340 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 IDRFLSNRAVDSPWYHMLISM-------YGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLA 129
            ||..|::...:.|...:.|.|       ||::.....:||..|::.||.:..|:|..|:||.:::
Worm     3 IDSNLTDFQCEYPAIDIGIHMKTLLAVGYGLVGALSLVGNLAVLLIVICRREMQTVTNIFISSVS 67

  Fly   130 ISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYPT 194
            .:||::...::..|.:....:.|.:|  ..:|..::::|.|.:....:::.|:|.|||.::..|.
Worm    68 AADLVITSFSLWATPLAYYQRVWHFG--KYMCYMVSIIQGLSLMWVPLTLAAVALDRYSLVASPF 130

  Fly   195 RDSLQFVGAVTILAGIWALALLLASPLFVYKELINTDTPALLQQIGLQDTIPYCIEDW--PSRNG 257
            |..:.....:.|:||||.....:.||:....:.:::..|.           .:|:|.|  ..::.
Worm   131 RQPMSKKTCLLIIAGIWMGGFAVLSPMIRMVDFVDSYGPC-----------HFCLESWDHDKQHY 184

  Fly   258 RFYYSIFSLCVQYLVPILIVSVAYFGI----------YNKLKSRITVVAVQASSAQRKVERGRRM 312
            |.:|.:..|.::..:|::::|:.::.|          :..|:|..||  .|::..:||
Worm   185 RLFYGLSVLVIRSAIPLVLISLCHWRIAVILNTQTKKFQTLRSASTV--TQSTDIRRK------- 240

  Fly   313 KRTNCLLISIAIIFGVSWLPLNFFNLYADM----ERSPVTQSMLVRYAI---CHMIGMSSACSNP 370
            :|...||:::.:||.||.|||:..|:..|:    :..||..:  ||:.|   ||...|:....||
Worm   241 QRLQTLLLAMVVIFAVSSLPLDLSNVLQDLIVVYQVRPVPDN--VRHFIFFFCHWTAMAGTLLNP 303

  Fly   371 LLYGWLNDNFRKEFQ 385
            |:|.:.|:|||::.|
Worm   304 LVYAYYNENFRRQIQ 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tm_4	98..>195	CDD:304433	24/96 (25%)
NPFR	NP_001246947.1	7tm_1	103..373	CDD:278431	72/288 (25%)
npr-7	NP_509570.3	7tmA_NPYR-like	25..317	CDD:320331	79/315 (25%)
		TM helix 1	27..51	CDD:320331	6/23 (26%)
		TM helix 2	60..82	CDD:320331	5/21 (24%)
		TM helix 3	98..120	CDD:320331	3/21 (14%)
		TM helix 4	141..157	CDD:320331	6/15 (40%)
		TM helix 5	186..209	CDD:320331	4/22 (18%)
		TM helix 6	241..266	CDD:320331	10/24 (42%)
		TM helix 7	285..310	CDD:320331	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAX7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810