DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NPFR and npr-8

DIOPT Version :9

Sequence 1:	NP_001246947.1	Gene:	NPFR / 40754	FlyBaseID:	FBgn0037408	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_741834.1	Gene:	npr-8 / 183869	WormBaseID:	WBGene00016984	Length:	510	Species:	Caenorhabditis elegans

Alignment Length:	506	Identity:	121/506 - (23%)
Similarity:	210/506 - (41%)	Gaps:	115/506 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DYLDLGTVHALNTTAINTSDLNETGSR------------PLDPVLIDRFLSNRAVD----SPWYH 87
            |..|||.:       :...|::....|            |.|.:.:.:|.......    :|:..
Worm    13 DIEDLGMI-------MEVKDIDNYCDRGISPNASNYLTYPFDGLCLQKFFYQLQTSLRRFTPYEE 70

  Fly    88 ML-ISMYGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKY 151
            :: .::|.::.|...:||.||::||:||..|||.||:.|||||:|:|:|.:..:|...:..:...
Worm    71 IIYTTVYIIISVAAVIGNGLVIMAVVRKKTMRTNRNVLILNLALSNLILAITNIPFLWLPSIDFE 135

  Fly   152 WPYGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVI--VYPTRDSLQFVGAVTILAGIWALA 214
            :||.  ...||...:|....|:.||::|:.:|.|||..:  :....:..|...||.:...||.::
Worm   136 FPYS--RFFCKFANVLPGSNIYCSTLTISVMAIDRYYSVKKLKIASNRKQCFHAVLVSLAIWIVS 198

  Fly   215 LLLASPLFVYKELINTDTPALLQQIGLQD-TIPYCIEDWPSRNGR---------------FYYSI 263
            .:|:.||.:|.|   |....::::|.:.| :....|..:..|..|               ...||
Worm   199 FILSLPLLLYYE---TSMLYVMREIRVVDQSGQEVIRSYGWRQCRLVSAGRLPDITQSIQLLMSI 260

  Fly   264 FSLCVQYLVPILIVSVAYFGI-----------------------------YNKLKSR-------- 291
            ..:...|:||:.::|:  |.:                             :|.||:.
Worm   261 LQVAFLYIVPLFVLSI--FNVKLTRFLKTNANKMSKTRAPPKRFDRSDSHHNSLKNNNNHTSSLR 323

  Fly   292 -ITVVAVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERSPVTQ---SML 352
             .::.::::|..:|. :..:|..||..|||::|..:...|.|........|.|.. :.|   :::
Worm   324 SPSMPSIRSSITERN-KTNQRTNRTTSLLIAMAGSYAALWFPFTLITFLIDFELI-INQDYVNLV 386

  Fly   353 VRY-AICHMIGMSSACSNPLLYGWLNDNFRKEFQEL---LCRC-SDTNVALNGHTTGCNVQAAAR 412
            .|. ..|.|:.|.|.|.||.|||:||.|||.||.::   ..|| :.:..|...|.   :|.:.|.
Worm   387 ERIDQTCKMVSMLSICVNPFLYGFLNTNFRHEFSDIYYRYIRCETKSQPAGRFHH---DVSSIAH 448

  Fly   413 RRRKLGAELSKGELKLLGPGGAQSGTAGGEGGLAATDFMTGHHEGGLRSAI 463
            .|:.   .:...|..||..|...:|..|....:            |.||::
Worm   449 HRQD---SVYNDEATLLTTGRQSNGKDGSSSPI------------GFRSSV 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tm_4	98..>195	CDD:304433	36/98 (37%)
NPFR	NP_001246947.1	7tm_1	103..373	CDD:278431	83/329 (25%)
npr-8	NP_741834.1	7tmA_NPYR-like	82..419	CDD:320331	92/345 (27%)
		TM helix 2	106..128	CDD:320331	10/21 (48%)
		TM helix 3	144..166	CDD:320331	6/21 (29%)
		TM helix 4	189..205	CDD:320331	3/15 (20%)
		TM helix 5	256..279	CDD:320331	7/24 (29%)
		TM helix 6	345..370	CDD:320331	8/24 (33%)
		TM helix 7	387..412	CDD:320331	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010