DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NPFR and npr-4

DIOPT Version :9

Sequence 1:	NP_001246947.1	Gene:	NPFR / 40754	FlyBaseID:	FBgn0037408	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001300304.1	Gene:	npr-4 / 182684	WormBaseID:	WBGene00007635	Length:	490	Species:	Caenorhabditis elegans

Alignment Length:	499	Identity:	130/499 - (26%)
Similarity:	218/499 - (43%)	Gaps:	86/499 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LDLGTVHALNTT-------AINTSDLNETGSRPLDPVLIDRFLSNRAVDSPWYHMLI--SMYGVL 96
            |::||:...|.|       .:|.||.....|        :.:|....:.|.||.||:  .:|.::
Worm     3 LEIGTITIGNITRARKFGERMNGSDCLNLNS--------ELWLYREDLSSRWYIMLVFAFLYLII 59

  Fly    97 IVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILC 161
            |..|.:||:.|::|:.|...::|..|||||:|:.||:::|..:..:|.:....|.|.:|..  ||
Worm    60 IAAGIIGNSCVILAITRNKSLQTVPNLFILSLSCSDIVVCCTSATITPITAFKKEWIFGEA--LC 122

  Fly   162 KTIAMLQALCIFVSTISITAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALALLLASPLFVYKE 226
            :....:..:.:..||.::|||:.|||.:|.:|.|..:....||.::|.|.|.|..:.||: ::|
Worm   123 RIAPFIAGISLCFSTFTLTAISIDRYILIRFPMRKPITHYQAVGVIAIICAFAATITSPI-MFK- 185

  Fly   227 LINTDTPALLQQIGLQDTI--PYCIEDW-PSRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKL 288
                      |::|..:..  .||.|:| .:.:.|..|....:.:|.::|:.|:.::|..|..|:
Worm   186 ----------QKLGEFENFCGQYCTENWGANESQRKIYGAALMFLQLVIPLTIIIISYTAISLKI 240

  Fly   289 ----------KSRITVVAVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADME 343
                      |.:.....::.|..||...  :|.:|||.:||.:.:.|..||:....||:..|.|
Worm   241 GQSMILKGAKKQKTDNWEMELSDQQRIAV--KRRQRTNRMLIGMVVAFACSWIWSVTFNILRDYE 303

  Fly   344 RSP---VTQSMLVRYAICHMIGMSSACSNPLLYGWLNDNFRKEFQELLCRC--------SDTNVA 397
            ..|   .||..:...| .|.|.|:|...|||||..||...|..|.:|:...        .|.:..
Worm   304 YLPELIKTQEYIFGIA-THCIAMTSTVWNPLLYAVLNLQLRAAFIDLMPHWLRRHLNLEGDNSSP 367

  Fly   398 LNGHTTGCNVQAAARRRRKLGAELSKG-ELKLLGPGGAQ---SGTAGGEGGLAATDFM---TGHH 455
            |..|.|       .....|.|:..:|. :...:.....|   |.:..|:....|..|.   :|..
Worm   368 LLNHPT-------MTITNKYGSTATKTVKATYINTSNGQPYVSTSLVGKVQPEAPSFKFNGSGRK 425

  Fly   456 EGGL-------RSAITESVALTDHNPVPSEV-------TKLMPR 485
            :..:       |:|..|...:|..:|.|.|:       ..::||
Worm   426 KSAMMRILVQKRNAEEEEQLITKESPSPPEIQMDTLCAASIIPR 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tm_4	98..>195	CDD:304433	32/96 (33%)
NPFR	NP_001246947.1	7tm_1	103..373	CDD:278431	83/285 (29%)
npr-4	NP_001300304.1	TM helix 1	52..76	CDD:320331	7/23 (30%)
		TM helix 2	85..107	CDD:320331	9/21 (43%)
		TM helix 3	123..145	CDD:320331	5/21 (24%)
		TM helix 4	166..182	CDD:320331	5/15 (33%)
		TM helix 5	211..234	CDD:320331	4/22 (18%)
		TM helix 6	273..298	CDD:320331	9/24 (38%)
		TM helix 7	314..339	CDD:320331	10/25 (40%)
		7tmA_NPYR-like	50..346	CDD:320331	92/312 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAX7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810