DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NPFR and Npy5r

DIOPT Version :9

Sequence 1:	NP_001246947.1	Gene:	NPFR / 40754	FlyBaseID:	FBgn0037408	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001345886.1	Gene:	Npy5r / 18168	MGIID:	108082	Length:	466	Species:	Mus musculus

Alignment Length:	441	Identity:	112/441 - (25%)
Similarity:	186/441 - (42%)	Gaps:	120/441 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TAINTSDLNETGSRPLDPVLIDRFLSNRAVDSPWYHMLISMYGVLIVFGALGNTLVVIAVIRKPI 116
            |..|||....|..    ||..|   ...:||...| .||.:|..:.:.|.:||.|:::||::|..
Mouse    36 TENNTSAARNTAF----PVWED---YRGSVDDLQY-FLIGLYTFVSLLGFMGNLLILMAVMKKRN 92

  Fly   117 MRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTISITA 181
            .:|..|..|.|||.||:|:.|...|.||..:|...|.:|..  :|..:..||.:.:.|||:.:.:
Mouse    93 QKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKA--MCHIMPFLQCVSVLVSTLILIS 155

  Fly   182 IAFDRYQVIVYPTRDSLQFVGAVTILAGIWALALLLASPLFVYKELI---NTDTPALLQQIGLQD 243
            ||..||.:|.:|..::|.......::|.:|.|...:.|||.|:..|:   .|...|||....|
Mouse   156 IAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYL-- 218

  Fly   244 TIPYCIEDWPSRNGRFYYSIFSLCVQYLVPILIVSVAYFGI-----------YNKLKS----RIT 293
                |:|.|||.:.|..::|..|.|||::|::.::|::..:           .|:|:.    .:|
Mouse   219 ----CVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLT 279

  Fly   294 VVAVQASSAQRK-------------VERGRRMKRTNCLLIS------------------------ 321
            :...:.|..|.|             ..|.|..|:|.|:|.:
Mouse   280 LHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLS 344

  Fly   322 ------------------------------------------------IAIIFGVSWLPLNFFNL 338
                                                            :.::|.|||:||:.|::
Mouse   345 PSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHV 409

  Fly   339 YADMERSPVT-QSMLVRYAICHMIGMSSACSNPLLYGWLNDNFRKEFQELL 388
            ..|...:.:: :...:.|.|||::||.|.|.||:|||:||:..:.:.:.|:
Mouse   410 VTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALI 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tm_4	98..>195	CDD:304433	35/96 (36%)
NPFR	NP_001246947.1	7tm_1	103..373	CDD:278431	91/373 (24%)
Npy5r	NP_001345886.1	7tmA_NPY5R	63..456	CDD:320520	101/401 (25%)
		TM helix 1	65..89	CDD:320520	9/23 (39%)
		TM helix 2	98..120	CDD:320520	10/21 (48%)
		TM helix 3	136..158	CDD:320520	6/21 (29%)
		TM helix 4	179..195	CDD:320520	4/15 (27%)
		TM helix 5	230..253	CDD:320520	7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..346		0/22 (0%)
		TM helix 6	387..409	CDD:320520	7/21 (33%)
		TM helix 7	424..449	CDD:320520	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I4080
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21241
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4017
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.060