DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NPFR and Npy2r

DIOPT Version :9

Sequence 1:	NP_001246947.1	Gene:	NPFR / 40754	FlyBaseID:	FBgn0037408	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_032757.2	Gene:	Npy2r / 18167	MGIID:	108418	Length:	381	Species:	Mus musculus

Alignment Length:	374	Identity:	122/374 - (32%)
Similarity:	190/374 - (50%)	Gaps:	45/374 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 GSRPLD--PVLIDRFLSNRAVDSPWYHMLISMYGVLIVFGALGNTLVVIAVIRKPIMRTARNLFI 125
            |..|.|  |.|||   |.:.|:.  ..:||..|..:|:.|.:||:||:..||:...|||..|.||
Mouse    30 GELPPDPEPELID---STKLVEV--QVILILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFI 89

  Fly   126 LNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVI 190
            .|||::|||:..:.:|.||...|...|..|  .:||..:...|.|.:.||||::|.||.||::.|
Mouse    90 ANLAVADLLVNTLCLPFTLTYTLMGEWKMG--PVLCHLVPYAQGLAVQVSTITLTVIALDRHRCI 152

  Fly   191 VYPTRDSLQFVGAVTILAGIWALALLLASPLFVYKELINTDTPALLQQIGLQDTIP-----YCIE 250
            ||.....:....:..|:...|.::.||||||.:::|            ..|.:.||     .|.|
Mouse   153 VYHLESKISKRISFLIIGLAWGISALLASPLAIFRE------------YSLIEIIPDFEIVACTE 205

  Fly   251 DWPSRNGRFY---YSIFSLCVQYLVPILIVSVAYFGIYNKLKSRITVVAVQASSAQRKVERGRRM 312
            .||......|   ||:.:|.:.|::|:.|:|.:|..|::||::.::..|......|      ||.
Mouse   206 KWPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLRNHVSPGAASDHYHQ------RRH 264

  Fly   313 KRTNCLLISIAIIFGVSWLPLNFFNLYADMERS--PVTQSMLVRYAICHMIGMSSACSNPLLYGW 375
            |.|. :|:.:.::|.||||||:.|.|..|::..  .:.:..|: :.:.|:|.|.|..:|||||||
Mouse   265 KMTK-MLVCVVVVFAVSWLPLHAFQLAVDIDSHVLDLKEYKLI-FTVFHIIAMCSTFANPLLYGW 327

  Fly   376 LNDNFRKEFQELLCRCSDTNVALNGHTTGCNVQAAARRRRKLGAELSKG 424
            :|.|:||.|.... ||.....|::.     .|....:.::.|..:.:.|
Mouse   328 MNSNYRKAFLSAF-RCEQRLDAIHS-----EVSMTFKAKKNLEVKKNNG 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tm_4	98..>195	CDD:304433	41/96 (43%)
NPFR	NP_001246947.1	7tm_1	103..373	CDD:278431	93/279 (33%)
Npy2r	NP_032757.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		3/6 (50%)
		7tmA_NPY2R	51..336	CDD:320521	106/306 (35%)
		TM helix 1	52..78	CDD:320521	11/25 (44%)
		TM helix 2	85..110	CDD:320521	12/24 (50%)
		TM helix 3	123..153	CDD:320521	12/29 (41%)
		TM helix 4	164..185	CDD:320521	8/20 (40%)
		TM helix 5	216..245	CDD:320521	9/28 (32%)
		TM helix 6	261..291	CDD:320521	15/36 (42%)
		TM helix 7	304..329	CDD:320521	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010