DRSC/TRiP Functional Genomics Resources

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Protein Alignment NPFR and Npy1r

DIOPT Version :9

Sequence 1:NP_001246947.1 Gene:NPFR / 40754 FlyBaseID:FBgn0037408 Length:489 Species:Drosophila melanogaster
Sequence 2:NP_001345884.1 Gene:Npy1r / 18166 MGIID:104963 Length:382 Species:Mus musculus


Alignment Length:355 Identity:108/355 - (30%)
Similarity:173/355 - (48%) Gaps:48/355 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 YGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSC 157
            ||.:|:.|..||..::|.::::..||...|:.|:||:.||||:.::.:|.|.:..|..:|.:|  
Mouse    46 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVYTLMDHWVFG-- 108

  Fly   158 SILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYP----TRDSLQFVGAVTILAGIWALALLLA 218
            ..:||....:|.:.|.||..|:..||.:|:|:|:.|    ..:...::| :|:   ||.||:..:
Mouse   109 ETMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYIG-ITV---IWVLAVASS 169

  Fly   219 SPLFVYKELINTDTPALLQQIGL---QDTIPYCIEDWPSRNGRFYYSIFSLCVQYLVPILIVSVA 280
            .|..:|:  |.||.|  .|.:.|   :|.. .|.:.:||.:.|..|:...|.:||..|:..:.:.
Mouse   170 LPFVIYQ--ILTDEP--FQNVSLAAFKDKY-VCFDKFPSDSHRLSYTTLLLVLQYFGPLCFIFIC 229

  Fly   281 YFGIYNKLKSRITVVAVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERS 345
            ||.||.:||.|..::.....|..|..|    .||.|.:|:||.:.|.|.||||..||...|....
Mouse   230 YFKIYIRLKRRNNMMDKIRDSKYRSSE----TKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQ 290

  Fly   346 PV-TQSMLVRYAICHMIGMSSACSNPLLYGWLNDNFRKEFQELLCRCS--------DTNVALNGH 401
            .: |.:..:.:.:||:..|.|.|.||:.||:||.||:::.|.....|.        :|......|
Mouse   291 IIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMH 355

  Fly   402 TTGCNVQAAARRRRKLGAELSKGELKLLGP 431
            |                 ::||..||...|
Mouse   356 T-----------------DVSKTSLKQASP 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NPFRNP_001246947.1 7tm_4 98..>195 CDD:304433 32/100 (32%)
7tm_1 103..373 CDD:278431 88/277 (32%)
Npy1rNP_001345884.1 7tmA_NPY1R 40..330 CDD:320517 98/298 (33%)
TM helix 1 42..66 CDD:320517 7/19 (37%)
TM helix 2 75..97 CDD:320517 9/21 (43%)
TM helix 3 113..135 CDD:320517 7/21 (33%)
TM helix 4 156..172 CDD:320517 6/19 (32%)
TM helix 5 208..231 CDD:320517 5/22 (23%)
TM helix 6 261..283 CDD:320517 11/21 (52%)
TM helix 7 298..323 CDD:320517 9/24 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 159 1.000 Domainoid score I4080
eggNOG 1 0.900 - - E33208_3BAX7
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D275052at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm43104
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24235
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.920

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