DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NPFR and npr-1

DIOPT Version :9

Sequence 1:	NP_001246947.1	Gene:	NPFR / 40754	FlyBaseID:	FBgn0037408	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_508816.1	Gene:	npr-1 / 180752	WormBaseID:	WBGene00003807	Length:	457	Species:	Caenorhabditis elegans

Alignment Length:	450	Identity:	117/450 - (26%)
Similarity:	197/450 - (43%)	Gaps:	84/450 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 ISMYGVLIVFGALGN-TLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWP 153
            :::|..|...|..|| ||:.:....|.:: :.:|:||||||.||.::|::::|:|.:..:.|.|.
Worm    30 LTVYLFLFFLGLFGNVTLIYVTCSHKALL-SVQNIFILNLAASDCMMCILSLPITPITNVYKNWY 93

  Fly   154 YGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALALLLA 218
            :|  ::||..|..:|.:.|||.|.|:.|||.|||.::|.|....|...||......:|.|:.::.
Worm    94 FG--NLLCHLIPCIQGISIFVCTFSLGAIALDRYILVVRPHSTPLSQRGAFLTTVLLWILSFVVT 156

  Fly   219 SPLFVYKELINTDTPALLQQIGLQDTIPYCIEDWPSRNGRFYYSIFSLCVQYLVPILIVSVAYFG 283
            .|.....::|......:...        :|.|.|.|...|..|::..:..|::||..:::..|..
Worm   157 LPYAFNMQMIEYTEERICGY--------FCTEKWESAKSRRAYTMIVMLAQFVVPFAVMAFCYAN 213

  Fly   284 IYNKLKSRI---------TVVAVQASSA------------------QRKVERGR---RMKRTNCL 318
            |.:.|..|.         ...|:::|.|                  :::.|:.|   :.:||..:
Worm   214 IVSVLSKRAQTKIRKMVERTSALESSCAFPSHGLEQYENELNEFLDKQEKEKQRVVLQNRRTTSI 278

  Fly   319 LISIAIIFGVSWLPLNFFNLYADMERSPVTQSMLVRYA------------ICHMIGMSSACSNPL 371
            |:::.:.||::|||.|..:|..:.:.   |||....|.            ..|.|.||:...||:
Worm   279 LVTMVVWFGITWLPHNVISLIIEYDD---TQSFFRLYGRDDYDISYLLNLFTHSIAMSNNVLNPV 340

  Fly   372 LYGWLNDNFRKEFQELLC-------RCSDTNVALNGHTTGCNVQAAARRRRKLGAELSKGELKLL 429
            ||.|||.:||    :|:.       |.||..:         |..:..:.:.....:...|..|:
Worm   341 LYAWLNPSFR----QLVIKTYFGDRRKSDRII---------NQTSVYKTKIVHDTKHLNGRAKI- 391

  Fly   430 GPGGAQSGTAGGEGGLAATDFMTGHHEGGLRSAITESVALTDHNPVPS-EVTKLMPRLEQ 488
              ||..|..|..|..|.:......:|..|.....|..|.|   |.|.| |::||:...|:
Worm   392 --GGGGSHEALKERELNSCSENLSYHVNGHTRTPTPEVQL---NEVSSPEISKLVAEPEE 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tm_4	98..>195	CDD:304433	38/97 (39%)
NPFR	NP_001246947.1	7tm_1	103..373	CDD:278431	82/312 (26%)
npr-1	NP_508816.1	7tmA_NPYR-like	27..351	CDD:320331	92/338 (27%)
		TM helix 1	29..53	CDD:320331	7/22 (32%)
		TM helix 2	62..84	CDD:320331	11/21 (52%)
		TM helix 3	100..122	CDD:320331	9/21 (43%)
		TM helix 4	143..159	CDD:320331	2/15 (13%)
		TM helix 5	189..212	CDD:320331	4/22 (18%)
		TM helix 6	273..298	CDD:320331	9/24 (38%)
		TM helix 7	321..346	CDD:320331	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3897
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.910