DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NPFR and npr-2

DIOPT Version :9

Sequence 1:	NP_001246947.1	Gene:	NPFR / 40754	FlyBaseID:	FBgn0037408	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_501701.2	Gene:	npr-2 / 177790	WormBaseID:	WBGene00003808	Length:	430	Species:	Caenorhabditis elegans

Alignment Length:	398	Identity:	103/398 - (25%)
Similarity:	183/398 - (45%)	Gaps:	65/398 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NSVRYLDDRHPLDYLDLGTVHALNTTAINTSDLNETGSRPLDPVLIDRFLSNR--AVDSPWYHML 89
            |.:|..|....|..:....:...::..||.::  ||         .||::...  ..:.|...:.
Worm    18 NMLRQSDGTRMLQEMRRKLIQLHSSQMINETE--ET---------CDRYIDKHPDMTNEPTVLVT 71

  Fly    90 IS-MYGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWP 153
            .| :|..:.:.|.|||:.|:...::...::|.:|:|||||..|::|:||.::|:|.:..:.|.|.
Worm    72 FSLLYLHIFLLGILGNSAVLYLTMKHRQLQTVQNIFILNLCASNVLMCLTSLPITFITNVYKQWF 136

  Fly   154 YGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALALLLA 218
            :.  |.:||.|.::|...|||||.|::|||.|||.::|.|.:..|....|:.|...||.:::::.
Worm   137 FS--SPVCKLIPLVQGASIFVSTFSLSAIALDRYNLVVRPHKQKLSSRSAMMIALLIWVISVVVC 199

  Fly   219 SPLFVYKELINTDTPALLQQIGLQDTIPYCIEDWPSRNGRFYYSIFSLCVQYLVPILIVSVAYFG 283
            .|...|.::...:        ||..  .||.|.||....|..|:...|..|:|.|...::..|:.
Worm   200 MPYGWYMDVEKLN--------GLCG--EYCSEHWPLAEVRKGYTFLVLITQFLFPFATMAFCYYN 254

  Fly   284 IYNKLKSRIT------------------------VVAVQASSAQRKVERGRRM------KRTNCL 318
            |:::|:.|:.                        :|::.|.:.|..:|..:|:      :||..:
Worm   255 IFSRLRQRVETKLKKLSERSQLLENSTTCGTTNHIVSINAEAVQNGLENKQRLAVLAQQRRTTTI 319

  Fly   319 LISIAIIFGVSWLPLNF---------FNLYADMERSPVTQSMLVRYAICHMIGMSSACSNPLLYG 374
            |..:.::|..:|||.|.         |..::|...:..|....:.....|:|.|.:..:||.||.
Worm   320 LSCMVLLFAFTWLPHNVVTLMIEYDGFFFHSDETSATSTDHTYIVSMTAHLISMLTNVTNPFLYA 384

  Fly   375 WLNDNFRK 382
            |||..|::
Worm   385 WLNPMFKE 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tm_4	98..>195	CDD:304433	39/96 (41%)
NPFR	NP_001246947.1	7tm_1	103..373	CDD:278431	82/308 (27%)
npr-2	NP_501701.2	7tmA_NPYR-like	70..394	CDD:320331	92/335 (27%)
		TM helix 1	72..96	CDD:320331	7/23 (30%)
		TM helix 2	105..127	CDD:320331	11/21 (52%)
		TM helix 3	143..165	CDD:320331	11/21 (52%)
		TM helix 4	186..202	CDD:320331	3/15 (20%)
		TM helix 5	230..253	CDD:320331	5/22 (23%)
		TM helix 6	314..339	CDD:320331	8/24 (33%)
		TM helix 7	362..387	CDD:320331	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920