Protein Alignment NPFR and npr-34

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_497057.2
• Gene: npr-34 / 175131
• WormBaseID: WBGene00013187
• Length: 613
• Species: Caenorhabditis elegans
• Alignment Length: 480
• Identity: 110/480 - (22%)
• Similarity: 185/480 - (38%)
• Gaps: 121/480 - (25%)

  Fly    15 DGEHLSGYASSSNSVRYLDDRHPLDYLDLGTVHALNTTAINTSDLNETGSRPLD---PVLIDR-- 74
            ||:..|.|.....:..|..|.         |....|.||:   |.|.|  .||.   .|.|.|
 Worm     4 DGDDPSCYMVQETTFDYEYDE---------TFDWSNMTAM---DCNCT--HPLHKYLEVCISRCT 54

  Fly    75 ------FLSNRAVDSPWYHMLISMYGVLIVF--GALGNTLVVIAVIRKPIMRTARNLFILNLAIS 131
                  |.|  ..|...:.:.:..:..|.||  |.:||::|:..|.|...||...|:|:.:|:.:
 Worm    55 VPDDTVFFS--MTDEELFEIALPGFLYLTVFLVGTIGNSMVIFVVNRFKRMRNVTNIFLASLSTA 117

  Fly   132 DLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYPTRD 196
            ||.|....:|:..|:.:|..|..|  ...|.::..:|....|.|.:::|.|:|:|:..|.||.|:
 Worm   118 DLCLIWFCVPIMFMKYMSHTWSMG--RFACYSVHYIQQFTCFCSVLTMTMISFERFLAIAYPMRN 180

  Fly   197 S-LQFVG-AVTILAGIWALALLLASPLFVYKELINTDTPALLQQIGLQDTIPYCIEDWPSRNGRF 259
            . ...:| |..::..||..:.:||.|     ..:..|....|...|  ..:.:|...:|:   :|
 Worm   181 IWFSSIGRAKKVILLIWMSSAVLAVP-----TAVRMDYETNLSLSG--QRVHWCRRRFPA---QF 235

  Fly   260 Y----------YSIFSLCVQYLVPILIVSVAYFG----IYNKLKSRITV--------------VA 296
            .          |:::.|.:..:.|:|.:|:.|..    :|...|.|:.:              |.
 Worm   236 LGYPRTSLNKAYAMYQLLLLIIFPVLTMSICYARVSAIVYKSSKDRVILSQAMVAFSKAATDAVT 300

  Fly   297 VQASSAQRKVERGRRMKRTNC-----------------------LLISIAIIFGVSWLPL---NF 335
            ....||...:...|.:|..|.                       :||||..::.|.|||.   ..
 Worm   301 FSGYSAIPMITTSRNLKTANTTIKSYSNHRNNRVAEANKKQIVQMLISIVCMYTVCWLPTIVDEL 365

  Fly   336 FNLYADMERSPVTQSMLVRYAICHM-IGMSS-----ACSNPLLYGWLNDNFRKEFQELLCRCSDT 394
            ...:..:.|:..||::.      || :|.::     :|.||:||.:::.|||..|:....|...
 Worm   366 LTSFGYICRTSNTQTLK------HMRMGFNALTYCQSCINPILYAFISQNFRSTFKTAYSRMKS- 423

  Fly   395 NVALNGHTTGCNVQAAARRRRKLGA 419
                       .:|.....|.::|:
 Worm   424 -----------RLQGVEEMRSRMGS 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	84/359 (23%)
		TM helix 1	88..114	CDD:320331	8/27 (30%)
		TM helix 2	121..146	CDD:320331	7/24 (29%)
		TM helix 3	161..191	CDD:320331	8/29 (28%)
		TM helix 4	202..223	CDD:320331	7/21 (33%)
		TM helix 5	258..287	CDD:320331	8/42 (19%)
		TM helix 6	310..340	CDD:320331	11/55 (20%)
		TM helix 7	352..377	CDD:320331	8/30 (27%)
npr-34	NP_497057.2	7tmA_GPRnna14-like	75..414	CDD:320132	84/356 (24%)
		TM helix 1	75..100	CDD:320132	8/24 (33%)
		TM helix 2	107..132	CDD:320132	7/24 (29%)
		TM helix 3	145..175	CDD:320132	8/29 (28%)
		TM helix 4	188..209	CDD:320132	6/25 (24%)
		TM helix 5	244..269	CDD:320132	6/24 (25%)
		TM helix 6	337..367	CDD:320132	8/29 (28%)
		TM helix 7	382..407	CDD:320132	8/30 (27%)