Protein Alignment NPFR and Brs3

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_033896.2
• Gene: Brs3 / 12209
• MGIID: 1100501
• Length: 399
• Species: Mus musculus
• Alignment Length: 432
• Identity: 105/432 - (24%)
• Similarity: 185/432 - (42%)
• Gaps: 90/432 - (20%)

  Fly    50 NTTAINTSDLNETGSRPLDPVLIDRFLSNRAV-------DSPWYHMLISMY----GVLIVFGALG 103
            |.|.|:.::..||.|         ..:||...       :||....|.::|    |::.| |.||
Mouse    10 NQTLISITNDTETSS---------SVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISV-GILG 64

  Fly   104 NTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQ 168
            |.:::....:...|:|..|:||.:||..||||.|..:|:.....|::.|.:|  .:.||.::.::
Mouse    65 NAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFG--KVGCKVLSFIR 127

  Fly   169 ALCIFVSTISITAIAFDRYQVIVYPTRDSLQFVGAVTIL------AGIWALALLLASPLFVYKEL 227
            ...:.||..::|.::.|||:.:|.|    |:......||      .|||.::::.|.|..::..:
Mouse   128 LTSVGVSVFTLTILSADRYKAVVKP----LERQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNV 188

  Fly   228 INTDTPALLQQIGLQDTIPYCIEDWPSRNGRF---------------YYSIFSLCVQYLVPILIV 277
                               |..:| |:||..|               .:|:....|.|::|:.|:
Mouse   189 -------------------YTFQD-PNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSII 233

  Fly   278 SVAYFGIYNKL-KSRITVVAVQASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYAD 341
            ||.|..|...| ||.:.:...:.|.|::::|..:|:.:|..:|::   :|.:.|||.:...||..
Mouse   234 SVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVA---LFALCWLPNHLLYLYHS 295

  Fly   342 MERSPVTQSMLVRYAI---CHMIGMSSACSNPLLYGWLNDNFRKEFQELLCRCSDT--------N 395
            ...........|.:.|   ..::..|::|.||....||:..|::.|:..|| |...        :
Mouse   296 FTYESYANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLC-CLKAEQPEPPLGD 359

  Fly   396 VALNGHTTGCNVQAAARRRRKLGAELSKGELKLLGPGGAQSG 437
            :.||..|....|.|..      .|.:|:..:.|.....|:.|
Mouse   360 IPLNNLTVMGRVPATG------SAHVSEISVTLFSGSSAKKG 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	81/324 (25%)
		TM helix 1	88..114	CDD:320331	8/29 (28%)
		TM helix 2	121..146	CDD:320331	11/24 (46%)
		TM helix 3	161..191	CDD:320331	8/29 (28%)
		TM helix 4	202..223	CDD:320331	7/26 (27%)
		TM helix 5	258..287	CDD:320331	10/43 (23%)
		TM helix 6	310..340	CDD:320331	8/29 (28%)
		TM helix 7	352..377	CDD:320331	7/27 (26%)
Brs3	NP_033896.2	7tm_GPCRs	48..341	CDD:475119	80/322 (25%)
		TM helix 1	50..74	CDD:320251	7/24 (29%)
		TM helix 2	83..105	CDD:320251	11/21 (52%)
		TM helix 3	121..143	CDD:320251	4/21 (19%)
		TM helix 4	166..182	CDD:320251	4/15 (27%)
		TM helix 5	215..238	CDD:320251	7/22 (32%)
		TM helix 6	270..292	CDD:320251	6/24 (25%)
		TM helix 7	309..334	CDD:320251	6/24 (25%)