Protein Alignment NPFR and oprk1

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001305708.1
• Gene: oprk1 / 100489465
• XenbaseID: XB-GENE-1011503
• Length: 420
• Species: Xenopus tropicalis
• Alignment Length: 402
• Identity: 101/402 - (25%)
• Similarity: 190/402 - (47%)
• Gaps: 64/402 - (15%)

  Fly    50 NTTAINTSDLNETGSRPLDPVLIDRFLSNRAVDSPWYHMLI-SMYGVLIVFGALGNTLVVIAVIR 113
            |.:|.....|||               .|....||...::| ::|.::.|.|.:||.||:..:||
 Frog    54 NVSAYPDLPLNE---------------GNHTSISPTISVIITAVYSMVFVVGLVGNALVMFVIIR 103

  Fly   114 KPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTIS 178
            ...|:||.|::|.|||::|.|: ..|||......|...||:|  .:|||.:..:....:|.|..:
 Frog   104 YTKMKTATNIYIFNLALADALV-TTTMPFQSTSFLMNSWPFG--DVLCKIVVSIDYYNMFTSIFT 165

  Fly   179 ITAIAFDRYQVIVYPTRDSLQF---VGAVTILAGIWALALLLASPLFVYKELINTDTPALLQQIG 240
            :|.::.|||..:.:|.: :|.|   :.|..|...||    :|:|.:.:        :..:|....
 Frog   166 LTMMSVDRYIAVCHPVK-ALDFRTPLKAKCINICIW----MLSSSVGI--------SAIVLGGTK 217

  Fly   241 LQDTIPYCIEDWPSRNGRFYY--SIFSLCV---QYLVPILIVSVAYFGIYNKLKSRITVVAVQAS 300
            :.|....|...:|:   .::|  ::..:||   .:::|:.|:::.|..:..:|||      |:..
 Frog   218 ISDGSTECALQFPT---HYWYWDTVMKMCVFIFAFIIPVFIITICYTLMILRLKS------VRLL 273

  Fly   301 SAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERSPVTQSMLVRYAICHMIGMSS 365
            |..|  |:.|.::|...|::.:..:|.|.|.|::.|.|...:...|.:.:::..|..|..:|.::
 Frog   274 SGSR--EKDRNLRRITRLVLVVVAVFIVCWTPIHIFVLVEALVDVPQSIAVVSIYYFCIALGYTN 336

  Fly   366 ACSNPLLYGWLNDNFRKEFQEL-------LCRCSDTNVALNGHTTGCNVQAAARRRRKLGAELSK 423
            :..||:||.:|::||::.|::.       |.|..::.|........|| :..:::...|..|::.
 Frog   337 SSLNPILYAFLDENFKRCFKDFCFPSKHRLDRQPNSRVGNTVQDPACN-RHGSQKPVXLAVEMTS 400

  Fly   424 GELKLLGPGGAQ 435
                 |.|.|.:
 Frog   401 -----LTPHGRE 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	82/304 (27%)
		TM helix 1	88..114	CDD:320331	9/26 (35%)
		TM helix 2	121..146	CDD:320331	10/24 (42%)
		TM helix 3	161..191	CDD:320331	8/29 (28%)
		TM helix 4	202..223	CDD:320331	6/20 (30%)
		TM helix 5	258..287	CDD:320331	6/33 (18%)
		TM helix 6	310..340	CDD:320331	9/29 (31%)
		TM helix 7	352..377	CDD:320331	7/24 (29%)
oprk1	NP_001305708.1	7tmA_Kappa_opioid_R	77..355	CDD:320219	82/304 (27%)
		TM helix 1	78..104	CDD:320219	9/25 (36%)
		TM helix 2	111..137	CDD:320219	10/26 (38%)
		TM helix 3	148..178	CDD:320219	8/29 (28%)
		TM helix 4	190..212	CDD:320219	6/33 (18%)
		TM helix 5	237..266	CDD:320219	5/28 (18%)
		TM helix 6	281..311	CDD:320219	9/29 (31%)
		TM helix 7	323..348	CDD:320219	7/24 (29%)
		YihI	<362..>408	CDD:470104	10/52 (19%)