DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NPFR and npy2r

DIOPT Version :9

Sequence 1:	NP_001246947.1	Gene:	NPFR / 40754	FlyBaseID:	FBgn0037408	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	XP_001343301.3	Gene:	npy2r / 100003852	ZFINID:	ZDB-GENE-040924-8	Length:	379	Species:	Danio rerio

Alignment Length:	363	Identity:	121/363 - (33%)
Similarity:	190/363 - (52%)	Gaps:	35/363 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TAINTSD------LNE-TGSRPLDPVLIDRFLSNRAVDSP----WYHMLISMYGVLIVFGALGNT 105
            |.||||:      ||: |.....|...:|..|.:...||.    ...:||..|..:|.||..||:
Zfish     5 TQINTSEDGTLSQLNQSTNCCAPDTAEVDAALLDGLEDSTKLVGVQVILILAYSTIIFFGMTGNS 69

  Fly   106 LVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQAL 170
            ||:..|.:...:.|..|.||:|||::|||:..:.:|.|||..|...|.:|  .::|..:...|.|
Zfish    70 LVIYVVYKFRNLHTVTNYFIVNLAVADLLVNTLCLPFTLMYTLYGEWKFG--QVMCYLLPYAQGL 132

  Fly   171 CIFVSTISITAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALALLLASPLFVYKELINTDTPAL 235
            .:.||||::..||.|||:.|||.....:.....|.::|..|..:.:|||||.:::|.:..|
Zfish   133 AVHVSTITLNVIALDRYRSIVYHMETKMSKDMCVVVIAITWVASAILASPLAIFREYVTFD---- 193

  Fly   236 LQQIGLQDTIPYCIEDWP--SRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKLKSRITVVAVQ 298
               :..:.||..|.|.||  |.:|.. |||....:||.:|:.|:|.||..|:|||::.:
Zfish   194 ---LSPEQTIQGCAEKWPGSSTDGTI-YSIAMFFLQYGLPLSIISFAYTRIWNKLRNHV------ 248

  Fly   299 ASSAQRKVERGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERSPV-TQSMLVRYAICHMIG 362
             |....:.:|.:|.::|..:|:::.::|.|||||.:.|.|..|::.|.: .:...:.|...|::.
Zfish   249 -SPGGGRSDRHQRRQKTTKMLVAVVVVFTVSWLPFHAFQLAVDIDSSVLEMKDFKLLYTAFHIVA 312

  Fly   363 MSSACSNPLLYGWLNDNFRKEFQELLCRCSDTNVALNG 400
            |.|..:||:||||:|.|:|..|..:. :|...|   ||
Zfish   313 MCSTFANPILYGWMNRNYRGSFVAVF-KCGRIN---NG 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tm_4	98..>195	CDD:304433	39/96 (41%)
NPFR	NP_001246947.1	7tm_1	103..373	CDD:278431	90/272 (33%)
npy2r	XP_001343301.3	7tm_GPCRs	51..334	CDD:333717	103/299 (34%)
		TM helix 1	53..77	CDD:320095	11/23 (48%)
		TM helix 2	86..108	CDD:320095	10/21 (48%)
		TM helix 3	124..146	CDD:320095	7/21 (33%)
		TM helix 4	167..183	CDD:320095	5/15 (33%)
		TM helix 5	215..238	CDD:320095	9/23 (39%)
		TM helix 6	262..287	CDD:320095	9/24 (38%)
		TM helix 7	302..327	CDD:320095	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I3972
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010