DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15580 and TCTE1

DIOPT Version :9

Sequence 1:	NP_649610.1	Gene:	CG15580 / 40743	FlyBaseID:	FBgn0037398	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_872345.2	Gene:	TCTE1 / 202500	HGNCID:	11693	Length:	501	Species:	Homo sapiens

Alignment Length:	613	Identity:	123/613 - (20%)
Similarity:	197/613 - (32%)	Gaps:	213/613 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ELFKPS-----------HQTLNLYSERNREIFAEAFIEGNLNTLVNLSVKSLAKLGIRGISPTLQ 84
            :|.|||           |...|:  .|.|.|.||. .|.:| .:|.|    |.:|.|:.|....|
Human    36 QLSKPSITPVPAKSRNPHPRANI--RRMRRIIAED-PEWSL-AIVPL----LTELCIQHIIRNFQ 92

  Fly    85 ASPQLMRIF-------YDALDVELPLR-DCYLIEDQRFWRRVVLSK--TLDKTLHLKRWNE--FD 137
            .:|.|.::.       .:.|..:|||. ...||:.:.:|.|..:.:  ......|...|..  |:
Human    93 KNPILKQMLPEHQQKVLNHLSPDLPLAVTANLIDSENYWLRCCMHRWPVCHVAHHGGSWKRMFFE 157

  Fly   138 WKAEGVSRKFVEQVESCPVNVKPQRRLAQLAEIVWQYVNSMHIRKLQALPDYAFIKHLESEPEED 202
            ...|.:.:.|:      |....| ..:..|..:...||..:|:.  |.||.......|....:.|
Human   158 RHLENLLKHFI------PGTTDP-AVILDLLPLCRNYVRRVHVD--QFLPPVQLPAQLRPGDQSD 213

  Fly   203 ISSESSDEEEISSDEPDTEMDEGEEEHKSSSSSSEAAITFWRAETENEDTIRRNARHLRNANRQQ 267
            ..||.             ||:|...:|                                    .|
Human   214 SGSEG-------------EMEEPTVDH------------------------------------YQ 229

  Fly   268 ARDAIARKREDRKERKRKRQEKLDALKNADQSGKKKKKKKKEPPIRDVFSINVAPEEGDDEDTKP 332
            ..|.:|..
Human   230 LGDLVAGL--------------------------------------------------------- 237

  Fly   333 DKRNKQLLLERIKRYDYPEDHCHHIDLGFVRYFENMMSLTLEFLGPPDVKD----YQSRYMKFSD 393
                               .|...:||.:                  ||||    ::.....|:.
Human   238 -------------------SHLEELDLVY------------------DVKDCGMNFEWNLFLFTY 265

  Fly   394 SDMVRLSKGLKYLPSLKTFRLRNSRLSMKKFRILTRALQNLDTLDEVDFGYDQMTDECSEGLAYL 458
            .|.:.|:..:|...:||.|:|..|::...|.||:.|:|.:...|:|:|...:.:.|..:.|.|.|
Human   266 RDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKL 330

  Fly   459 LKRPLMYRSIQLEHNKLGANCAIVLGEALSQSQVGVLEYLGLAHNPLNELALHSLITCII---GT 520
            |....: |.:.|.:|::.|..|..|..|             |||| .|.::|:..:.||.   |.
Human   331 LSHSRL-RVLNLANNQVRAPGAQSLAHA-------------LAHN-TNLISLNLRLNCIEDEGGQ 380

  Fly   521 PHVWALNISGINTTL----GSFSRDIGTLLRS----HTPLMSLEMAAINIGISQGNQILRSLEKN 577
            ....||..:...|||    ...|....|||..    :|.|.|:.::..:||:..|.|:|..:..|
Human   381 ALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDN 445

  Fly   578 TRILYADFRECELSFDQEFEVDMIVRRN 605
            ..:|..|.|..:::.:.|:.:...:..|
Human   446 KTLLEFDLRLSDVAQESEYLIGQALYAN 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15580	NP_649610.1	DUF1168	<243..337	CDD:284149	3/93 (3%)
CG15580	NP_649610.1	LRR_RI	<378..517	CDD:238064	39/142 (27%)
TCTE1	NP_872345.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		5/19 (26%)
		LRR_RI	179..489	CDD:238064	86/455 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..222		6/32 (19%)
		LRR 1	308..321		3/12 (25%)
		leucine-rich repeat	309..335	CDD:275380	8/25 (32%)
		LRR 2	335..355		5/20 (25%)
		leucine-rich repeat	336..363	CDD:275380	11/41 (27%)
		LRR 3	363..383		5/19 (26%)
		leucine-rich repeat	364..391	CDD:275380	6/26 (23%)
		LRR 4	391..411		6/19 (32%)
		leucine-rich repeat	392..419	CDD:275380	7/26 (27%)
		LRR 5	419..439		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870