Protein Alignment CG15580 and DRC5

DIOPT Version :10

• Sequence 1: NP_649610.1
• Gene: CG15580 / 40743
• FlyBaseID: FBgn0037398
• Length: 743
• Species: Drosophila melanogaster
• Sequence 2: NP_872345.2
• Gene: DRC5 / 202500
• HGNCID: 11693
• Length: 501
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 123/613 - (20%)
• Similarity: 197/613 - (32%)
• Gaps: 213/613 - (34%)

  Fly    31 ELFKPS-----------HQTLNLYSERNREIFAEAFIEGNLNTLVNLSVKSLAKLGIRGISPTLQ 84
            :|.|||           |...|:  .|.|.|.||. .|.:| .:|.|    |.:|.|:.|....|
Human    36 QLSKPSITPVPAKSRNPHPRANI--RRMRRIIAED-PEWSL-AIVPL----LTELCIQHIIRNFQ 92

  Fly    85 ASPQLMRIF-------YDALDVELPLR-DCYLIEDQRFWRRVVLSK--TLDKTLHLKRWNE--FD 137
            .:|.|.::.       .:.|..:|||. ...||:.:.:|.|..:.:  ......|...|..  |:
Human    93 KNPILKQMLPEHQQKVLNHLSPDLPLAVTANLIDSENYWLRCCMHRWPVCHVAHHGGSWKRMFFE 157

  Fly   138 WKAEGVSRKFVEQVESCPVNVKPQRRLAQLAEIVWQYVNSMHIRKLQALPDYAFIKHLESEPEED 202
            ...|.:.:.|:      |....| ..:..|..:...||..:|:.  |.||.......|....:.|
Human   158 RHLENLLKHFI------PGTTDP-AVILDLLPLCRNYVRRVHVD--QFLPPVQLPAQLRPGDQSD 213

  Fly   203 ISSESSDEEEISSDEPDTEMDEGEEEHKSSSSSSEAAITFWRAETENEDTIRRNARHLRNANRQQ 267
            ..||.             ||:|...:|                                    .|
Human   214 SGSEG-------------EMEEPTVDH------------------------------------YQ 229

  Fly   268 ARDAIARKREDRKERKRKRQEKLDALKNADQSGKKKKKKKKEPPIRDVFSINVAPEEGDDEDTKP 332
            ..|.:|..
Human   230 LGDLVAGL--------------------------------------------------------- 237

  Fly   333 DKRNKQLLLERIKRYDYPEDHCHHIDLGFVRYFENMMSLTLEFLGPPDVKD----YQSRYMKFSD 393
                               .|...:||.:                  ||||    ::.....|:.
Human   238 -------------------SHLEELDLVY------------------DVKDCGMNFEWNLFLFTY 265

  Fly   394 SDMVRLSKGLKYLPSLKTFRLRNSRLSMKKFRILTRALQNLDTLDEVDFGYDQMTDECSEGLAYL 458
            .|.:.|:..:|...:||.|:|..|::...|.||:.|:|.:...|:|:|...:.:.|..:.|.|.|
Human   266 RDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKL 330

  Fly   459 LKRPLMYRSIQLEHNKLGANCAIVLGEALSQSQVGVLEYLGLAHNPLNELALHSLITCII---GT 520
            |....: |.:.|.:|::.|..|..|..|             |||| .|.::|:..:.||.   |.
Human   331 LSHSRL-RVLNLANNQVRAPGAQSLAHA-------------LAHN-TNLISLNLRLNCIEDEGGQ 380

  Fly   521 PHVWALNISGINTTL----GSFSRDIGTLLRS----HTPLMSLEMAAINIGISQGNQILRSLEKN 577
            ....||..:...|||    ...|....|||..    :|.|.|:.::..:||:..|.|:|..:..|
Human   381 ALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDN 445

  Fly   578 TRILYADFRECELSFDQEFEVDMIVRRN 605
            ..:|..|.|..:::.:.|:.:...:..|
Human   446 KTLLEFDLRLSDVAQESEYLIGQALYAN 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15580	NP_649610.1	RNA1	<391..595	CDD:444072	59/214 (28%)
DRC5	NP_872345.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		5/19 (26%)
		LRR_RI	179..489	CDD:238064	86/455 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..222		6/32 (19%)
		LRR 1	308..321		3/12 (25%)
		leucine-rich repeat	309..335	CDD:275380	8/25 (32%)
		LRR 2	335..355		5/20 (25%)
		leucine-rich repeat	336..363	CDD:275380	11/41 (27%)
		LRR 3	363..383		5/19 (26%)
		leucine-rich repeat	364..391	CDD:275380	6/26 (23%)
		LRR 4	391..411		6/19 (32%)
		leucine-rich repeat	392..419	CDD:275380	7/26 (27%)
		LRR 5	419..439		6/19 (32%)