Protein Alignment CtsL3 and CTSV

DIOPT Version :10

• Sequence 1: NP_649608.1
• Gene: CtsL3 / 40741
• FlyBaseID: FBgn0037396
• Length: 336
• Species: Drosophila melanogaster
• Sequence 2: NP_001324.2
• Gene: CTSV / 1515
• HGNCID: 2538
• Length: 334
• Species: Homo sapiens
• Alignment Length: 325
• Identity: 116/325 - (35%)
• Similarity: 182/325 - (56%)
• Gaps: 35/325 - (10%)

  Fly    27 DTEWDQYKAKYNKQY-RNRDKYHRALYEQRVLAVESHNQLYLQGKVAFKMGLNKFSD-TDQRI-- 87
            ||:|.|:||.:.:.| .|.:.:.||::|:.:..:|.||..|.|||..|.|.:|.|.| |::..
Human    26 DTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQ 90

  Fly    88 --------LFNYRSSIPAPLETSTNALTETVNYKRYDQITEGIDWRQYGYISPVGDQGTECLSCW 144
                    .|........||               :..:.:.:|||:.||::||.:| .:|.|||
Human    91 MMGCFRNQKFRKGKVFREPL---------------FLDLPKSVDWRKKGYVTPVKNQ-KQCGSCW 139

  Fly   145 AFSTSGVLEAHMAKKYGNLVPLSPKHLVDCV-PYPNNGCSGGWVSVAFNYTRDH-GIATKESYPY 207
            |||.:|.||..|.:|.|.||.||.::||||. |..|.||:||:::.||.|.::: |:.::|||||
Human   140 AFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPY 204

  Fly   208 EPVSGECLWKSDRSAGTLSGYVTLGNYDERELAEVVYNIGPVAVSIDHLHEEFDQYSGGVLSIPA 272
            ..|...|.::.:.|....:|:..:....|:.|.:.|..:||::|::|..|..|..|..|:...|.
Human   205 VAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPD 269

  Fly   273 CRSKRQDLTHSVLLVGF---GTHRKWGDYWIIKNSYGTDWGESGYLKLARNANNMCGVASLPQYP 334
            |.||  :|.|.||:||:   |.:.....||::|||:|.:||.:||:|:|::.||.||:|:...||
Human   270 CSSK--NLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYP 332

  Fly   335  334
            Human   333  332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsL3	NP_649608.1	Inhibitor_I29	30..85	CDD:462410	22/56 (39%)
		Peptidase_C1A	120..334	CDD:239068	87/218 (40%)
CTSV	NP_001324.2	Inhibitor_I29	29..87	CDD:214853	22/57 (39%)
		Peptidase_C1	114..332	CDD:425470	87/220 (40%)