Protein Alignment CtsL3 and CTSH

DIOPT Version :10

• Sequence 1: NP_649608.1
• Gene: CtsL3 / 40741
• FlyBaseID: FBgn0037396
• Length: 336
• Species: Drosophila melanogaster
• Sequence 2: NP_004381.2
• Gene: CTSH / 1512
• HGNCID: 2535
• Length: 335
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 109/323 - (33%)
• Similarity: 166/323 - (51%)
• Gaps: 22/323 - (6%)

  Fly    19 ELGLTAVSDTEWDQYKAKYNKQYRNRDKYHR-ALYEQRVLAVESHNQLYLQGKVAFKMGLNKFSD 82
            ||.:.::....:..:.:|:.|.|...:.:|| ..:......:.:||    .|...|||.||:|||
Human    24 ELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHN----NGNHTFKMALNQFSD 84

  Fly    83 TD-QRILFNYRSSIPAPLE-TSTNALTETVNYKRYDQITEGIDWRQYG-YISPVGDQGTECLSCW 144
            .. ..|...|..|.|.... |.:|.|..|..|      ...:|||:.| ::|||.:||. |.|||
Human    85 MSFAEIKHKYLWSEPQNCSATKSNYLRGTGPY------PPSVDWRKKGNFVSPVKNQGA-CGSCW 142

  Fly   145 AFSTSGVLEAHMAKKYGNLVPLSPKHLVDCV-PYPNNGCSGGWVSVAFNY-TRDHGIATKESYPY 207
            .|||:|.||:.:|...|.::.|:.:.||||. .:.|:||.||..|.||.| ..:.||..:::|||
Human   143 TFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPY 207

  Fly   208 EPVSGECLWKSDRSAGTLSGYVTLGNYDERELAEVVYNIGPVAVSIDHLHEEFDQYSGGVLSIPA 272
            :...|.|.::..::.|.:.....:..|||..:.|.|....||:.:.: :.::|..|..|:.|..:
Human   208 QGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFE-VTQDFMMYRTGIYSSTS 271

  Fly   273 CRSKRQDLTHSVLLVGFGTHRKWG-DYWIIKNSYGTDWGESGYLKLARNANNMCGVASLPQYP 334
            |......:.|:||.||:|  .|.| .|||:|||:|..||.:||..:.| ..||||:|:...||
Human   272 CHKTPDKVNHAVLAVGYG--EKNGIPYWIVKNSWGPQWGMNGYFLIER-GKNMCGLAACASYP 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsL3	NP_649608.1	Inhibitor_I29	30..85	CDD:462410	16/56 (29%)
		Peptidase_C1A	120..334	CDD:239068	80/217 (37%)
CTSH	NP_004381.2	Inhibitor_I29	35..90	CDD:462410	16/58 (28%)
		Peptidase_C1	117..332	CDD:425470	82/220 (37%)