Protein Alignment CtsL3 and Ctsb

DIOPT Version :10

• Sequence 1: NP_649608.1
• Gene: CtsL3 / 40741
• FlyBaseID: FBgn0037396
• Length: 336
• Species: Drosophila melanogaster
• Sequence 2: NP_031824.1
• Gene: Ctsb / 13030
• MGIID: 88561
• Length: 339
• Species: Mus musculus
• Alignment Length: 373
• Identity: 85/373 - (22%)
• Similarity: 143/373 - (38%)
• Gaps: 110/373 - (29%)

  Fly    13 ILLLLVELGLTAVSDTEWDQYKAKYNKQYRNRDKYHRALYEQRVLAVESHNQLYLQGKVAFKMG- 76
            ::||...|.||:..|                :..:| .|.:..:..:...|..:..|:..:.:.
Mouse     5 LILLSCLLALTSAHD----------------KPSFH-PLSDDLINYINKQNTTWQAGRNFYNVDI 52

  Fly    77 --LNKFSDT-------DQRILFNYRSSIPAPLETSTNALTETVNYKRYDQITEGIDWRQYGYISP 132
              |.|...|       ..|:.|.....:|           ||.:.:.        .|.....|..
Mouse    53 SYLKKLCGTVLGGPKLPGRVAFGEDIDLP-----------ETFDARE--------QWSNCPTIGQ 98

  Fly   133 VGDQGTECLSCWAFSTSGVLEA-------HMAKKYGNLVPLSPKHLVDCVPYP-NNGCSGGWVSV 189
            :.|||: |.|||||   |.:||       |...:..  |.:|.:.|:.|.... .:||:||:.|.
Mouse    99 IRDQGS-CGSCWAF---GAVEAISDRTCIHTNGRVN--VEVSAEDLLTCCGIQCGDGCNGGYPSG 157

  Fly   190 AFNYTRDHGIATKESY-------PY-------------EPVSGE---------C------LWKSD 219
            |:::....|:.:...|       ||             .|.:||         |      .:|.|
Mouse   158 AWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRPPCTGEGDTPRCNKSCEAGYSPSYKED 222

  Fly   220 RSAGTLSGYVTLGNYDERELAEVVYNIGPVAVSIDHLHEEFDQYSGGVLSIPACRSKRQDLT--H 282
            :..|..|  .::.|..:..:|| :|..|||..:.. :..:|..|..||.     :.:..|:.  |
Mouse   223 KHFGYTS--YSVSNSVKEIMAE-IYKNGPVEGAFT-VFSDFLTYKSGVY-----KHEAGDMMGGH 278

  Fly   283 SVLLVGFGTHRKWG-DYWIIKNSYGTDWGESGYLKLARNANNMCGVAS 329
            ::.::|:|...  | .||:..||:..|||::|:.|:.|..|: ||:.|
Mouse   279 AIRILGWGVEN--GVPYWLAANSWNLDWGDNGFFKILRGENH-CGIES 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsL3	NP_649608.1	Inhibitor_I29	30..85	CDD:462410	7/64 (11%)
		Peptidase_C1A	120..334	CDD:239068	67/256 (26%)
Ctsb	NP_031824.1	Propeptide_C1	26..65	CDD:462365	6/38 (16%)
		Peptidase_C1A_CathepsinB	81..328	CDD:239111	70/280 (25%)