DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rm62 and DDX46

DIOPT Version :9

Sequence 1:	NP_524243.2	Gene:	Rm62 / 40739	FlyBaseID:	FBgn0003261	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001287789.1	Gene:	DDX46 / 9879	HGNCID:	18681	Length:	1032	Species:	Homo sapiens

Alignment Length:	728	Identity:	230/728 - (31%)
Similarity:	364/728 - (50%)	Gaps:	78/728 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SSEKCITQRRHFLFSSASSSGTFASSSSLCTEQRQQFHGSRRNRETILFPSTYSSLQAQSQRAFR 101
            |.|:..::.|....|.:.|.|..:.|||...:.::..:.||...:|....|:....:.:..:  .
Human    79 SRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKDKDDK--E 141

  Fly   102 DSSKPDSDDYVDSIPKAEQRTRTRKSLFNDPDERTEEIKIEGVMAPHDRDFGHSGRGGRGGDRGG 166
            |..:.|:.::..:  |.|:..|.||.......|...:..:|.: ....::.....:|.:......
Human   142 DEKEKDAGNFDQN--KLEEEMRKRKERVEKWREEQRKKAMENI-GELKKEIEEMKQGKKWSLEDD 203

  Fly   167 DDRRGGGGGGNRFGGGGGGGDYHGIRNGRVEKRRDDRGGGNRFGGGGGFGDRRGG---------- 221
            ||.........:.|....|.:...:.....|.:.:.:....|...|||..:::.|
Human   204 DDDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVV 268

  Fly   222 ----------------------------------------GGGGSQDLPMRPVDFSNL--APFKK 244
                                                    |....|...:.|||...:  .||:|
Human   269 TTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRK 333

  Fly   245 NFYQEHPNVANRSPYEVQRYREEQE-ITVRGQ-VPNPIQDFSEVHLPDYVMKEIRRQGYKAPTAI 307
            |||.|.|.:|..|..||..:|.|.| |||:|: .|.||:.:.:..:...::..:::.||:.||.|
Human   334 NFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPI 398

  Fly   308 QAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQQPLQRGDGPIALVLAPTRELAQQIQQ 372
            |.|..|..|||.:.:||||||||||:.::||...||.:|:.|:.|:||||:::.||||||.||.:
Human   399 QTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITK 463

  Fly   373 VATEFGSSSYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGS---TNLKRCTYLVL 434
            ...:|..:..:|..||:||.....|:.:|:||.||::.||||:||.|:|.|   |||:|.||:||
Human   464 ECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVL 528

  Fly   435 DEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVKQLAEDFLGNYIQINIGSLELSANHN 499
            ||||||.|||||||:.:||..:||||||:|:|||:|:.::.||...|...|::.:|...:..: :
Human   529 DEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCS-D 592

  Fly   500 IRQVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVRFIRSFGVRCGAIHGDK 564
            :.|.|.|.:|..|..||..||....::    |.:||||:.:...|.|::.:......|.::||..
Human   593 VEQQVIVIEEEKKFLKLLELLGHYQES----GSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGI 653

  Fly   565 SQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSEDYIHRIGRTGRSNTKGT 629
            .|.:||.::.:|::|...:||||.||||||||..:..|:|:..|.:.|||:||.|||||:..||.
Human   654 DQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGY 718

  Fly   630 SFAFFTKNNAKQAKALVDVLREANQEINPALENLARN--SRYDGGGGRSRYGGGGGGGRFGGGGF 692
            ::.|.|::.|:.|..::..|..:...:.|.||.|..:  .:....|...:...|     |.|.||
Human   719 AYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSG-----FSGKGF 778

  Fly   693 K----KGSLSNGR 701
            |    :.:|:|.|
Human   779 KFDETEQALANER 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	PTZ00424	280..656	CDD:185609	157/378 (42%)
		DEADc	283..488	CDD:238167	99/207 (48%)
		HELICc	499..633	CDD:238034	51/133 (38%)
DDX46	NP_001287789.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..228		27/153 (18%)
		SrmB	344..826	CDD:223587	183/458 (40%)
		DEADc_DDX46	361..582	CDD:350711	105/220 (48%)
		Q motif	372..400		5/27 (19%)
		DEAD box	529..532		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920