DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rm62 and DBP2

DIOPT Version :9

Sequence 1:	NP_524243.2	Gene:	Rm62 / 40739	FlyBaseID:	FBgn0003261	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_014287.3	Gene:	DBP2 / 855611	SGDID:	S000005056	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	563	Identity:	307/563 - (54%)
Similarity:	371/563 - (65%)	Gaps:	36/563 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 GGDDRRGGGGGGNRFGGGGGGGDYHGIRNGRVEKRRDDRGGGNRFGGGGGFGDRRGGGGGGS--- 226
            ||.|::     .|:......|||:.|.||       .||...|....||.:   |||.||.|
Yeast     4 GGRDQQ-----YNKTNYKSRGGDFRGGRN-------SDRNSYNDRPQGGNY---RGGFGGRSNYN 53

  Fly   227 --QDL--PMRPVDFSNLAPFKKNFYQEHPNVANRSPYEVQRYREEQEITVRG-QVPNPIQDFSEV 286
              |:|  |....:...|..|:||||.||.:|.:||..|:.::|:|.|:|:.| .:|.||..|.|.
Yeast    54 QPQELIKPNWDEELPKLPTFEKNFYVEHESVRDRSDSEIAQFRKENEMTISGHDIPKPITTFDEA 118

  Fly   287 HLPDYVMKEIRRQGYKAPTAIQAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQQPLQR 351
            ..||||:.|::.:|:..||.||.||||:|:||.:.||||.|||||||.|.||.|||||.|..|..
Yeast   119 GFPDYVLNEVKAEGFDKPTGIQCQGWPMALSGRDMVGIAATGSGKTLSYCLPGIVHINAQPLLAP 183

  Fly   352 GDGPIALVLAPTRELAQQIQQVATEFGSSSYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLI 416
            |||||.||||||||||.|||...::||.||.:|||||:||.||..|:|||.||.|||||||||||
Yeast   184 GDGPIVLVLAPTRELAVQIQTECSKFGHSSRIRNTCVYGGVPKSQQIRDLSRGSEIVIATPGRLI 248

  Fly   417 DFLSAGSTNLKRCTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVKQLAEDFL 481
            |.|..|.|||||.||||||||||||||||||||||||.|||||||||||||||||||||||.|:|
Yeast   249 DMLEIGKTNLKRVTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVKQLAADYL 313

  Fly   482 GNYIQINIGSLELSANHNIRQVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNL 546
            .:.||:.:|||||||:|||.|:|:|..:|.|.::|...|......:|.  |.:||..|||..|::
Yeast   314 NDPIQVQVGSLELSASHNITQIVEVVSDFEKRDRLNKYLETASQDNEY--KTLIFASTKRMCDDI 376

  Fly   547 VRFIRSFGVRCGAIHGDKSQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNS 611
            .:::|..|....||||||.|.|||:||:|||:|:|.|:|||||||||:||.||.||||:|.|.|.
Yeast   377 TKYLREDGWPALAIHGDKDQRERDWVLQEFRNGRSPIMVATDVAARGIDVKGINYVINYDMPGNI 441

  Fly   612 EDYIHRIGRTGRSNTKGTSFAFFTKNNAKQAKALVDVLREANQEINPALENLARNSRYDGGGGRS 676
            |||:||||||||:...||:.:|||:.|......|:.::|||||.|.|.|....|.|.   |||..
Yeast   442 EDYVHRIGRTGRAGATGTAISFFTEQNKGLGAKLISIMREANQNIPPELLKYDRRSY---GGGHP 503

  Fly   677 RYGGGGGGGRFGGGGFKKGSLSNGRGFGGG-----GGGGGEGR 714
            |||||.||   .||..::|....|||..||     ||.|..||
Yeast   504 RYGGGRGG---RGGYGRRGGYGGGRGGYGGNRQRDGGWGNRGR 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	PTZ00424	280..656	CDD:185609	236/375 (63%)
		DEADc	283..488	CDD:238167	147/204 (72%)
		HELICc	499..633	CDD:238034	70/133 (53%)
DBP2	NP_014287.3	PTZ00110	4..492	CDD:240273	282/504 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	266	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	569	1.000	Inparanoid score	I155
Isobase	1	0.950	-	0	Normalized mean entropy	S387
OMA	1	1.010	-	-		QHG53695
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	1	1.000	-	-		otm46701
orthoMCL	1	0.900	-	-		OOG6_100364
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R290
SonicParanoid	1	1.000	-	-		X504
TreeFam	1	0.960	-	-
	14	13.810