Protein Alignment Rm62 and PRP5

DIOPT Version :10

• Sequence 1: NP_524243.2
• Gene: Rm62 / 40739
• FlyBaseID: FBgn0003261
• Length: 719
• Species: Drosophila melanogaster
• Sequence 2: NP_009796.1
• Gene: PRP5 / 852539
• SGDID: S000000441
• Length: 849
• Species: Saccharomyces cerevisiae
• Alignment Length: 751
• Identity: 214/751 - (28%)
• Similarity: 343/751 - (45%)
• Gaps: 141/751 - (18%)

  Fly    30 ISPRSGASSEKCITQRRHFLFSSASSSGTFASSSSLCTEQRQQFHGSRRNRETI-LFPSTYSSLQ 93
            |..:...:.|..:.:||..|.........|.:.....|.:......|...::|. .|......::
Yeast     4 IDSKQNINRESLLEERRKKLAKWKQKKAQFDAQKEHQTSRNDIVTNSLEGKQTTEKFTERQERVK 68

  Fly    94 AQSQR---AFRDSSKPDSDDYVDSIPKAEQRTRTRKSL---FNDPDERTEEIKI-----EGVM-A 146
            .:.::   .||.|.:|.|   |....|..:|::.:|.:   |:|.|:  .||.:     |.:. |
Yeast    69 EELRKRKNEFRKSDEPVS---VKPSKKKSKRSKVKKKISFDFSDDDD--SEIGVSFRSKEHIQKA 128

  Fly   147 P-HDR------DFGHSGRGGR-GGDRGGDDRRGGGGGGNRFGGGGGGGDYHGIRNGRVEKRRDDR 203
            | ||.      :|..|.:..: ...:|..||                ||...:.:...|.
Yeast   129 PEHDNEKDPLDEFMTSLKEEKMSNSKGMYDR----------------GDILDVEDQLFEL----- 172

  Fly   204 GGGNRFGGGGGFGDRRGGGGGGSQDLPMRP-VDFSNLA----------------------PFKKN 245
                                ||:.|..:.. .|.||:|                      ||:||
Yeast   173 --------------------GGTDDEDVEDNTDNSNIAKIAKLKAKKRVKQIYYSPEELEPFQKN 217

  Fly   246 FYQEHPNVANRSPYEVQRYR-EEQEITVRGQ-VPNPIQDFSEVHL-PDYVMKEIRRQGYKAPTAI 307
            ||.|...|::.|..||:..| ....|.::|. .|.|:..:|::.| .|.::....:..:.:.|.|
Yeast   218 FYIESETVSSMSEMEVEELRLSLDNIKIKGTGCPKPVTKWSQLGLSTDTMVLITEKLHFGSLTPI 282

  Fly   308 QAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQQPLQRGD-GPIALVLAPTRELAQQIQ 371
            |:|..|..|||.:.:||:|||||||:.|:||.:..:..|:||.:.: ||:.|:||||||||.||.
Yeast   283 QSQALPAIMSGRDVIGISKTGSGKTISYLLPLLRQVKAQRPLSKHETGPMGLILAPTRELALQIH 347

  Fly   372 QVATEF-GSSSYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGSTNL---KRCTYL 432
            :..|:| .:.:.:|:.|..||:....|:.||:||.|||:|||||.||.|:.....|   ||.|::
Yeast   348 EEVTKFTEADTSIRSVCCTGGSEMKKQITDLKRGTEIVVATPGRFIDILTLNDGKLLSTKRITFV 412

  Fly   433 VLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVKQLAEDFLGNYIQINIGSLELSAN 497
            |:|||||:.|:||||||.:|:..:|||:|.:::|||:|.:::..|...|.:.|.|.|.|..: .|
Yeast   413 VMDEADRLFDLGFEPQITQIMKTVRPDKQCVLFSATFPNKLRSFAVRVLHSPISITINSKGM-VN 476

  Fly   498 HNIRQVVDVCDEFSKEEKLKTLLSDIY------------------DTSESPGKIIIFVETKRRVD 544
            .|::|...:|  .|::||...|:..|:                  |..|...|.||||.::...|
Yeast   477 ENVKQKFRIC--HSEDEKFDNLVQLIHERSEFFDEVQSENDGQSSDVEEVDAKAIIFVSSQNICD 539

  Fly   545 NLVRFIRSFGVRCGAIHGDKSQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQ 609
            .:.:.:.:.|:...|||..|...||...|.:|:..|::||:.|:|.:|||:|..:..||.::..:
Yeast   540 FISKKLLNAGIVTCAIHAGKPYQERLMNLEKFKREKNSILLCTEVLSRGLNVPEVSLVIIYNAVK 604

  Fly   610 NSEDYIHRIGRTGRSNTKGTSFAFFTKNNAKQAKALVDVLR-EANQEINP--ALENLARNSRYDG 671
            ....|:|..|||.|.:..||:......:....|..|...:| |..:.::|  |.|....:::::
Yeast   605 TFAQYVHTTGRTARGSRSGTAITLLLHDELSGAYILSKAMRDEEIKALDPLQAKELQEMSAKFE- 668

  Fly   672 GGGRSRYGGGGGGGRFGGGGFKKGSLSNGRGFGGGG 707
                              .|.|||.....:||||.|
Yeast   669 ------------------SGMKKGKFRLSKGFGGKG 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	DEAD-like_helicase_N	231..669	CDD:475120	165/489 (34%)
PRP5	NP_009796.1	DEADc_DDX46	244..468	CDD:350711	93/223 (42%)
		SrmB	255..707	CDD:440279	154/454 (34%)
		KH-I_PRP5_like	749..837	CDD:411902