back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rm62 and DDX59

DIOPT Version :10

Sequence 1:	NP_524243.2	Gene:	Rm62 / 40739	FlyBaseID:	FBgn0003261	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001026895.2	Gene:	DDX59 / 83479	HGNCID:	25360	Length:	619	Species:	Homo sapiens

Alignment Length:	421	Identity:	147/421 - (34%)
Similarity:	236/421 - (56%)	Gaps:	20/421 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 APFKKNF-YQEHPNVANRSPYEVQRYREEQEITVRGQ-VPNPIQDFSEVHLPDYVMKEIRRQGYK 302
            :|...:: |:|||.:.|....:::..:::..|.|:|| |..||.||....||:.:...:::.||:
Human   160 SPLNASYVYKEHPFILNLQEDQIENLKQQLGILVQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYE 224

  Fly   303 APTAIQAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQQPLQRGDGPIALVLAPTRELA 367
            .||.||.|..|:.:.|.:.:..|.||||||..::||.|:     :.|.....|.||:|.||||||
Human   225 VPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIM-----RALFESKTPSALILTPTRELA 284

  Fly   368 QQIQQVATEFGSS-SYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGSTNLKRCTY 431
            .||::.|.|..|. ..::...:.||.|...|:..||:..:::|||||||:|.:...|..|.....
Human   285 IQIERQAKELMSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKI 349

  Fly   432 LVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVKQLAEDFLGNYIQINIGSLELSA 496
            :|:||||.||.|||:.|:..|:..|..|.||::.|||.|..::|||...|.|.::|..|...|..
Human   350 VVVDEADTMLKMGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPC 414

  Fly   497 NHNIRQVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVRFIRSF-GVRCGAI 560
             .|:||::...::.:|::||..:|:| ....:.|  :::||:.|...|.|...::.. |::..:|
Human   415 -ANVRQIILWVEDPAKKKKLFEILND-KKLFKPP--VLVFVDCKLGADLLSEAVQKITGLKSISI 475

  Fly   561 HGDKSQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSEDYIHRIGRTGRSN 625
            |.:|||.||..:|:....|...::|:|.|..||||:..::.|:|||.|.:.::|:|:|||.||..
Human   476 HSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRLG 540

  Fly   626 TKGTSFAFFTKNN-------AKQAKALVDVL 649
            ..||:..|...|:       ||:.|....:|
Human   541 QNGTAITFINNNSKRLFWDIAKRVKPTGSIL 571

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.