Protein Alignment Rm62 and DDX50

DIOPT Version :10

• Sequence 1: NP_524243.2
• Gene: Rm62 / 40739
• FlyBaseID: FBgn0003261
• Length: 719
• Species: Drosophila melanogaster
• Sequence 2: NP_076950.1
• Gene: DDX50 / 79009
• HGNCID: 17906
• Length: 737
• Species: Homo sapiens
• Alignment Length: 783
• Identity: 190/783 - (24%)
• Similarity: 298/783 - (38%)
• Gaps: 242/783 - (30%)

  Fly   113 DSIPKAEQRTRTRKSLFN-DPDERTEEIKIEGVMAPHDRDFGHSGRGGRGGDRGGDDRRGGGGGG 176
            :|..|..|::..|||..: |.||:: |.:..||  ..|.|...:.:........||...|.....
Human    21 ESQKKERQKSDRRKSRHHYDSDEKS-ETRENGV--TDDLDAPKAKKSKMKEKLNGDTEEGFNRLS 82

  Fly   177 NRFGGGGGGGDYHGIRNGRVEKRRDDRGGGNRFGGGGGFGDRRGGGGGGSQDLPMRPVDFSNLAP 241
            :.|              .:..|.|                         .:|||...:|......
Human    83 DEF--------------SKSHKSR-------------------------RKDLPNGDIDEYEKKS 108

  Fly   242 FKKNFYQEHPNVANRSPYEVQRYREEQEITVRGQVPNPIQDFSEVHLPDYVMKEIRRQG--YKAP 304
            .:.:......:.::.:..|....||::|           ..||...:.:..:|.::.:|  |..|
Human   109 KRVSSLDTSTHKSSDNKLEETLTREQKE-----------GAFSNFPISEETIKLLKGRGVTYLFP 162

  Fly   305 TAIQAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHI-NNQQPLQRGDGPIALVLAPTRELAQ 368
            ..::..| |: ..|.:.:..|:||:|||..:.:|.|..: .||:.:::...|..||||||||||
Human   163 IQVKTFG-PV-YEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELA- 224

  Fly   369 QIQQVATEFGS-SSYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGSTNLKRCTYL 432
              .|||.:|.. :..:...|.:||.....|:..::.|.:|::.||||:.|.|.:|..:|.:..::
Human   225 --NQVAKDFKDITRKLSVACFYGGTSYQSQINHIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHV 287

  Fly   433 VLDEADRMLDMGFEPQIRKIV-------SQIRPDRQTLMWSATWPKEVKQLAEDFL-GNYIQIN- 488
            ||||.|:|||:||..|:..|:       |:..|  |||::|||.|:.|.::|:.:: ..|.|::
Human   288 VLDEVDQMLDLGFAEQVEDIIHESYKTDSEDNP--QTLLFSATCPQWVYKVAKKYMKSRYEQVDL 350

  Fly   489 IGSLELSANHNIRQVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVR--FIR 551
            :|.:...|...:..:...|....:...:..:| .:|..||  |:.|||.|||:.|..:..  .|:
Human   351 VGKMTQKAATTVEHLAIQCHWSQRPAVIGDVL-QVYSGSE--GRAIIFCETKKNVTEMAMNPHIK 412

  Fly   552 SFGVRCGAIHGDKSQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSEDYIH 616
            . ..:|  :|||.:||:|:..|:.||.|...:||||:|||||||:..:..||....||:.|.|||
Human   413 Q-NAQC--LHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIH 474

  Fly   617 RIGRTGRSNTKGTSFAFF------------------------------TKNNAKQA--------- 642
            |.|||||:...|....|:                              .|:.:..|
Human   475 RSGRTGRAGRTGICICFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSY 539

  Fly   643 ----------------KALVDVL------------------------------------------ 649
                            |..||.|
Human   540 AAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESLEEIQDVSCA 604

  Fly   650 -REANQEIN------------------------------------------------PALE---- 661
             :|.|::::                                                |.:|
Human   605 WKELNRKLSSNAVSQITRMCLLKGNMGVCFDVPTTESERLQAEWHDSDWILSVPAKLPEIEEYYD 669

  Fly   662 -NLARNSRY-----DGGGGRSRYGGGGGGGRFG---GGGFKKGSLSNGRGFGGGGGGGGEGRHSR 717
             |.:.|||.     .|..|||...||..|||.|   ..|.:.||..:||...|.......|.|.|
Human   670 GNTSSNSRQRSGWSSGRSGRSGRSGGRSGGRSGRQSRQGSRSGSRQDGRRRSGNRNRSRSGGHKR 734

  Fly   718 -FD 719
             ||
Human   735 SFD 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	DEAD-like_helicase_N	231..669	CDD:475120	145/603 (24%)
DDX50	NP_076950.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..131		25/151 (17%)
		Q motif	137..165		6/27 (22%)
		SrmB	139..526	CDD:440279	128/399 (32%)
		DEVD box	290..293		2/2 (100%)
		GUCT_RHII_Gualpha_beta	568..659	CDD:240593	2/90 (2%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..737		23/68 (34%)