Protein Alignment Rm62 and Ddx42

DIOPT Version :10

• Sequence 1: NP_524243.2
• Gene: Rm62 / 40739
• FlyBaseID: FBgn0003261
• Length: 719
• Species: Drosophila melanogaster
• Sequence 2: NP_082350.3
• Gene: Ddx42 / 72047
• MGIID: 1919297
• Length: 929
• Species: Mus musculus
• Alignment Length: 728
• Identity: 249/728 - (34%)
• Similarity: 370/728 - (50%)
• Gaps: 98/728 - (13%)

  Fly    13 GGATPRPTACGWGNLLLISPRSGASSEKCITQRRHFLFSSASSSGTFASSSSLCTEQRQQFH--G 75
            |..|.|  ..|:|...:   .:|...|..:.|:.|..|.:||||..|..|:   ..|...|:  |
Mouse     7 GPGTKR--GFGFGGFAI---SAGKKEEAKLPQQSHSAFGAASSSSGFGKSA---PPQLPSFYKIG 63

  Fly    76 SRRNRETILFPSTYSSLQAQSQRAFRDSSKPDSDDYVDSIPKAEQRTRTRKSLFNDP-DERTEEI 139
            |:|        :.:....|..:....|||..|    :..||  .:.:.||:...:.| |..:::.
Mouse    64 SKR--------ANFDEENAYFEDEEEDSSNVD----LPYIP--AENSPTRQQFHSKPADSDSDDD 114

  Fly   140 KIEGVMAPHDRDFGHSGRGGRGGDRGGDDRRGGGGGGNRFGGGGGGGDYHGIRN----------- 193
            .:|..||..:   ..:.|..:..:....:|:                :..|||:
Mouse   115 PLEAFMAEVE---DQAARDMKRLEEKDKERK----------------NVKGIRDDIEEEDDQEAY 160

  Fly   194 ----------GRVEKRRDDR----GGGNRFGGGGGFGDRRGGGGGGSQDLPMRPVDFSNL--APF 242
                      |.|::..:|.    ..||.........|            |:.|:|.|.:  .||
Mouse   161 FRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPSKKIID------------PLPPIDHSEIDYPPF 213

  Fly   243 KKNFYQEHPNVANRSPYEVQRYREEQEITVRGQV-PNPIQDFSEVHLPDYVMKEIRRQGYKAPTA 306
            :||||.||..:.|.:|.::...|.:..:.|.|.. |.|...|:.....:.:|.:||:..|..||.
Mouse   214 EKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTP 278

  Fly   307 IQAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQQPLQRGDGPIALVLAPTRELAQQIQ 371
            ||.||.|:|:||.:.:||||||||||..:|.|.::||.:|:.|:.||||||:::.|||||.|||.
Mouse   279 IQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIH 343

  Fly   372 QVATEFGSSSYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGSTNLKRCTYLVLDE 436
            .....||.:..:|:..|:||.....|.:.||.|.|||:.|||||||.:...:|||:|.:|||.||
Mouse   344 AECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDE 408

  Fly   437 ADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVKQLAEDFLGNYIQINIGSLELSANHNIR 501
            ||||.|||||.|:|.|.|.:|||||||::|||:.|::::||.|.|.:.|::..|.:. .||.::.
Mouse   409 ADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIG-EANEDVT 472

  Fly   502 QVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVRFIRSFGVRCGAIHGDKSQ 566
            |:|::.  .|...|...|...:.:.:.| |.:::||..|...:.|...::..|...|.:|||..|
Mouse   473 QIVEIL--HSGPSKWNWLTRRLVEFTSS-GSVLLFVTKKANAEELASNLKQEGHNLGLLHGDMDQ 534

  Fly   567 SERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSEDYIHRIGRTGRSNTKGTSF 631
            |||:.|:.:|:.....:||||||||||||:..||.|||:|..::.:.:.||||||||:..||.::
Mouse   535 SERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAY 599

  Fly   632 AFFTKNNAKQAKALVDVLREANQEINPALENLA------RNSRYDGGGGRS-RYGGGGGGGRFGG 689
            ...|..::..|..||..|..|||.::..|.:||      |.||:.||.|:. ..||||.|.|...
Mouse   600 TLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERP 664

  Fly   690 GGFKKGSLSNGRG 702
            |   .||.::.||
Mouse   665 G---LGSENSDRG 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	DEAD-like_helicase_N	231..669	CDD:475120	187/446 (42%)
Ddx42	NP_082350.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..119		27/110 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..203		4/32 (13%)
		Q motif	253..281		8/27 (30%)
		SrmB	254..678	CDD:440279	184/428 (43%)
		DEAD box	407..410		2/2 (100%)
		dermokine	<644..>889	CDD:455732	14/34 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..682		5/16 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	723..929
		Necessary for interaction with TP53BP2. /evidence=ECO:0000250|UniProtKB:Q86XP3	739..828